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r(MGI:Epo)

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Entity

Name
Epo
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

path(MESH:Anemia) increases act(r(MGI:Epo), ma(tscript)) View Subject | View Object

During anemia (n  6), kidney EPO mRNA transcription increased 20-fold relative to control mice (n  5, P  0.001; Fig. 9A). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
Text Location
Results

path(MESH:Anemia) causesNoChange act(r(MGI:Epo), ma(tscript)) View Subject | View Object

Heart EPO mRNA transcription was not significantly different in anemic mice relative to control mice (P  0.35). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Heart
Text Location
Results

path(MESH:Anemia) increases r(MGI:Epo) View Subject | View Object

Despite the preserved tissue PO2 level during subacute anemia, we demonstrated an increase in HIF-dependent mRNA levels of EPO, HO-1, and GAPDH. This finding is consistent with other experimental studies that have also demonstrated increases in HIF-dependent mRNA expression in the absence of a clear reduction in brain PtO2 (12, 23). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Anemia
Text Location
Discussion

Out-Edges 0

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.