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bp(MESH:Eryptosis)

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Entity

Name
Eryptosis
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 12

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation bp(MESH:Eryptosis) View Subject | View Object

An increase in RBC phosphatidylserine exposure in -thalassemia patients has been shown to be connected with eryptosis, the suicidal death of RBCs [49]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation bp(MESH:Eryptosis) View Subject | View Object

Eryptosis is the apoptotic-like suicidal process of erythrocytes, and is characterized by cell shrinkage and phosphatidylserine (PS) expression on the outer membrane. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
Text Location
Introduction

a(CHEBI:ceramide) increases bp(MESH:Eryptosis) View Subject | View Object

Eryptosis is tightly regulated and triggered by a wide range of (endogenous) mediators and stimuli such as calcium signaling, ceramide formation, complement activation, energy depletion, eicosanoid release, hemolysin, and heme [140–142]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

a(CHEBI:heme) increases bp(MESH:Eryptosis) View Subject | View Object

Eryptosis is tightly regulated and triggered by a wide range of (endogenous) mediators and stimuli such as calcium signaling, ceramide formation, complement activation, energy depletion, eicosanoid release, hemolysin, and heme [140–142]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

a(MESH:Eicosanoids) increases bp(MESH:Eryptosis) View Subject | View Object

Eryptosis is tightly regulated and triggered by a wide range of (endogenous) mediators and stimuli such as calcium signaling, ceramide formation, complement activation, energy depletion, eicosanoid release, hemolysin, and heme [140–142]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

bp(GO:"complement activation") increases bp(MESH:Eryptosis) View Subject | View Object

Eryptosis is tightly regulated and triggered by a wide range of (endogenous) mediators and stimuli such as calcium signaling, ceramide formation, complement activation, energy depletion, eicosanoid release, hemolysin, and heme [140–142]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

bp(MESH:"Calcium Signaling") increases bp(MESH:Eryptosis) View Subject | View Object

Eryptosis is tightly regulated and triggered by a wide range of (endogenous) mediators and stimuli such as calcium signaling, ceramide formation, complement activation, energy depletion, eicosanoid release, hemolysin, and heme [140–142]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

p(PFAM:Leukocidin) increases bp(MESH:Eryptosis) View Subject | View Object

Eryptosis is tightly regulated and triggered by a wide range of (endogenous) mediators and stimuli such as calcium signaling, ceramide formation, complement activation, energy depletion, eicosanoid release, hemolysin, and heme [140–142]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

p(PFAM:Leukocidin) increases bp(MESH:Eryptosis) View Subject | View Object

The same applies to hemolysin. For one thing, the pore-forming toxin hemolysin is one the pathogens’ tools of causing hemolysis or releasing hemoglobin and poorly available iron [139]; then again it trigger eryptosis, one mechanism of protecting against hemolysis [142]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

path(MESH:Anemia) association bp(MESH:Eryptosis) View Subject | View Object

On the other hand, eryptosis is associated with anemia, microcirculatory derangement, and thrombosis [142, 144]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

path(MESH:Sepsis) positiveCorrelation bp(MESH:Eryptosis) View Subject | View Object

In 2007, Kempe10 et al. reported that erythrocytes showed an apoptotic tendency in septic patients. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
Text Location
Introduction

path(MESH:Thrombosis) association bp(MESH:Eryptosis) View Subject | View Object

On the other hand, eryptosis is associated with anemia, microcirculatory derangement, and thrombosis [142, 144]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

Out-Edges 6

bp(MESH:Eryptosis) increases a(MESH:"Cell-Derived Microparticles") View Subject | View Object

Interestingly, a recent study demonstrated that, in severe hemolytic disease (sickle cell anemia), at least one third of plasma heme was associated with membrane vesicle structures (microparticles) that were generated from erythrocytes during hemolysis [24]. PubMed:26875449

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:Eryptosis) positiveCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

An increase in RBC phosphatidylserine exposure in -thalassemia patients has been shown to be connected with eryptosis, the suicidal death of RBCs [49]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

bp(MESH:Eryptosis) positiveCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Eryptosis is the apoptotic-like suicidal process of erythrocytes, and is characterized by cell shrinkage and phosphatidylserine (PS) expression on the outer membrane. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
Text Location
Introduction

bp(MESH:Eryptosis) positiveCorrelation path(MESH:Sepsis) View Subject | View Object

In 2007, Kempe10 et al. reported that erythrocytes showed an apoptotic tendency in septic patients. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
Text Location
Introduction

bp(MESH:Eryptosis) association path(MESH:Anemia) View Subject | View Object

On the other hand, eryptosis is associated with anemia, microcirculatory derangement, and thrombosis [142, 144]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

bp(MESH:Eryptosis) association path(MESH:Thrombosis) View Subject | View Object

On the other hand, eryptosis is associated with anemia, microcirculatory derangement, and thrombosis [142, 144]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.