Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Appears in Networks 3

In-Edges 2

path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:ceramide) View Subject | View Object

Sphingolipids are also strongly implicated in AD pathology, with upregulated levels of ceramide, a key component in sphingolipid metabolism, detected in the early phase of AD [80]. PubMed:29758300

Out-Edges 3

a(CHEBI:ceramide) increases act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

Conversely, many endogenous small molecules, comprising metal cations, ceramides and polyamines, can enhance the activity of PP2A enzymes (Reviewed in Voronkov et al.,2011). PubMed:24653673

a(CHEBI:ceramide) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Sphingolipids are also strongly implicated in AD pathology, with upregulated levels of ceramide, a key component in sphingolipid metabolism, detected in the early phase of AD [80]. PubMed:29758300

a(CHEBI:ceramide) increases bp(MESH:Eryptosis) View Subject | View Object

Eryptosis is tightly regulated and triggered by a wide range of (endogenous) mediators and stimuli such as calcium signaling, ceramide formation, complement activation, energy depletion, eicosanoid release, hemolysin, and heme [140–142]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.