a(CHEBI:ceramide)
Sphingolipids are also strongly implicated in AD pathology, with upregulated levels of ceramide, a key component in sphingolipid metabolism, detected in the early phase of AD [80]. PubMed:29758300
Conversely, many endogenous small molecules, comprising metal cations, ceramides and polyamines, can enhance the activity of PP2A enzymes (Reviewed in Voronkov et al.,2011). PubMed:24653673
Sphingolipids are also strongly implicated in AD pathology, with upregulated levels of ceramide, a key component in sphingolipid metabolism, detected in the early phase of AD [80]. PubMed:29758300
Eryptosis is tightly regulated and triggered by a wide range of (endogenous) mediators and stimuli such as calcium signaling, ceramide formation, complement activation, energy depletion, eicosanoid release, hemolysin, and heme [140–142]. PubMed:29956069
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