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a(CHEBI:"phosphatidyl-L-serine")

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Entity

Name
phosphatidyl-L-serine
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 18

a(CHEBI:"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine") decreases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

The Zn2þ (20 mM)-induced expression of PS on erythrocytes, which was inhibited by TPEN, was not observed by other divalent cations, including Mg2þ and Ca2þ (Fig. 2A). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

a(CHEBI:"zinc(2+)") increases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

The Zn2þ (20 mM)-induced expression of PS on erythrocytes, which was inhibited by TPEN, was not observed by other divalent cations, including Mg2þ and Ca2þ (Fig. 2A). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

a(CHEBI:Thrombin) positiveCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

These RBC microparticles can initiate and propogate thrombin generation (Rubin et al, 2013). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(HM:"Atheroma lipid") negativeCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Elevated cholesterol, oxy-cholesterol, lyso-phospholipid and decreased phosphatidylserine were found in atheromatous lipids compared to controls (supplemental Table II). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"stored erythrocytes") increases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Stored RBCs undergo a complex structural and metabolic impairment that includes leakage of hemoglobin from the cells and hemolysis, reduced energy and NO production, formation of toxic products, such as lysophospholipids and free iron, phosphatidylserine exposure and shedding MPs [59]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(MESH:"Erythrocytes, Abnormal") positiveCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Under conditions of apoptosis or RBC damage, such as high shear rates, inflammation, or oxidative stress, RBCs can lose membrane asymmetry and expose phosphatidylserine [43]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(MESH:"Erythrocytes, Abnormal") positiveCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Phosphatidylserine externalization and shedding are mediated by increased cellular Ca-flux and play an important role in natural RBC senescence [44]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

bp(MESH:"Calcium Signaling") increases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Phosphatidylserine externalization and shedding are mediated by increased cellular Ca-flux and play an important role in natural RBC senescence [44]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

bp(MESH:Eryptosis) positiveCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

An increase in RBC phosphatidylserine exposure in -thalassemia patients has been shown to be connected with eryptosis, the suicidal death of RBCs [49]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

bp(MESH:Eryptosis) positiveCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Eryptosis is the apoptotic-like suicidal process of erythrocytes, and is characterized by cell shrinkage and phosphatidylserine (PS) expression on the outer membrane. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
Text Location
Introduction

p(HGNC:ALB) decreases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

HRG and HSA both inhibited PS expression when their concentrations were increased to 10 and 100 mg/mL (Fig. 2B). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(HGNC:ANXA5) decreases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

To determine the role of PS in the Zn2þ-induced aggregation of erythrocytes, we used Annexin V to block PS expression on the erythrocyte membrane. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(HGNC:HRG) decreases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

HRG and HSA both inhibited PS expression when their concentrations were increased to 10 and 100 mg/mL (Fig. 2B). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(HGNC:HRG) decreases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Surprisingly, HRG at high concentration (100 mg/mL) significantly decreased PS expression on erythrocytes. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(MGI:Hrg) decreases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Although a significant difference in PS expressionwas not observed among the CLP groups treated with PBS, HSA or HRG, incubation of erythrocytes for 4 h enabled the observation of beneficial effects of HRG on PS expression on erythrocytes (Fig. 5B). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

path(HP:Hypercoagulability) positiveCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

The abnormal phospholipid membrane asymmetry present in the RBCs of b-thalassaemia and SCD patients, with resultant phosphatidylserine exposure, appears to play a significant role in the aetiology of the observed hypercoagulable state and in the link between haemolysis and thrombosis (Ataga et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

path(MESH:"Blood Coagulation") positiveCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Furthermore, phosphatidylserine is actively maintained on the inner leaflet of the bilayer membrane and, when externalized, is a recognition signal for cell clearance or for activation of coagulation (Zwaal & Schroit, 1997). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:Thrombosis) positiveCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Because of the large numbers of RBCs present in the blood, even a small fraction of RBCs with phosphatidylserine exposure can result in prothrombotic conditions. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

Out-Edges 12

a(CHEBI:"phosphatidyl-L-serine") negativeCorrelation a(HM:"Atheroma lipid") View Subject | View Object

Elevated cholesterol, oxy-cholesterol, lyso-phospholipid and decreased phosphatidylserine were found in atheromatous lipids compared to controls (supplemental Table II). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation path(HP:Hypercoagulability) View Subject | View Object

The abnormal phospholipid membrane asymmetry present in the RBCs of b-thalassaemia and SCD patients, with resultant phosphatidylserine exposure, appears to play a significant role in the aetiology of the observed hypercoagulable state and in the link between haemolysis and thrombosis (Ataga et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation a(MESH:"Erythrocytes, Abnormal") View Subject | View Object

Phosphatidylserine externalization and shedding are mediated by increased cellular Ca-flux and play an important role in natural RBC senescence [44]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") increases path(MESH:Hemolysis) View Subject | View Object

The abnormal phospholipid membrane asymmetry present in the RBCs of b-thalassaemia and SCD patients, with resultant phosphatidylserine exposure, appears to play a significant role in the aetiology of the observed hypercoagulable state and in the link between haemolysis and thrombosis (Ataga et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") increases path(MESH:Thrombosis) View Subject | View Object

The abnormal phospholipid membrane asymmetry present in the RBCs of b-thalassaemia and SCD patients, with resultant phosphatidylserine exposure, appears to play a significant role in the aetiology of the observed hypercoagulable state and in the link between haemolysis and thrombosis (Ataga et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

Because of the large numbers of RBCs present in the blood, even a small fraction of RBCs with phosphatidylserine exposure can result in prothrombotic conditions. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation path(MESH:"Blood Coagulation") View Subject | View Object

Furthermore, phosphatidylserine is actively maintained on the inner leaflet of the bilayer membrane and, when externalized, is a recognition signal for cell clearance or for activation of coagulation (Zwaal & Schroit, 1997). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation a(CHEBI:Thrombin) View Subject | View Object

These RBC microparticles can initiate and propogate thrombin generation (Rubin et al, 2013). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") decreases a(CHEBI:"nitric oxide") View Subject | View Object

In addition to cell-free Hb, membrane structural modification, externalization of phosphatidylserine,21 decreased cell membrane deformability,22,23 and increased endothelial adherence24 could alter vascular NO homeostasis. PubMed:27308950

Appears in Networks:
Annotations
MeSH
Endothelium, Vascular
Text Location
Introduction

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation a(MESH:"Erythrocytes, Abnormal") View Subject | View Object

Under conditions of apoptosis or RBC damage, such as high shear rates, inflammation, or oxidative stress, RBCs can lose membrane asymmetry and expose phosphatidylserine [43]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation bp(MESH:Eryptosis) View Subject | View Object

An increase in RBC phosphatidylserine exposure in -thalassemia patients has been shown to be connected with eryptosis, the suicidal death of RBCs [49]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation bp(MESH:Eryptosis) View Subject | View Object

Eryptosis is the apoptotic-like suicidal process of erythrocytes, and is characterized by cell shrinkage and phosphatidylserine (PS) expression on the outer membrane. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
Text Location
Introduction

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.