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p(HGNC:HRG)

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Entity

Name
HRG
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

p(HGNC:F2) positiveCorrelation deg(p(HGNC:HRG)) View Subject | View Object

The decrease was due to the reduction in HRG gene expression, deposition of HRG on immunothrombi and degradation of HRG by thrombin. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Discussion

Out-Edges 6

p(HGNC:HRG) decreases bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

HRG strongly inhibited the aggregation at a concentration of 1 mg/mL, whereas the same concentration of HSA showed no effect (Fig. 1B). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(HGNC:HRG) decreases bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

HRG and HSA both strongly inhibited aggregation when the concentration was increased to 100 mg/mL (Supplementary Fig. 1). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(HGNC:HRG) decreases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

HRG and HSA both inhibited PS expression when their concentrations were increased to 10 and 100 mg/mL (Fig. 2B). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(HGNC:HRG) decreases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Surprisingly, HRG at high concentration (100 mg/mL) significantly decreased PS expression on erythrocytes. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(HGNC:HRG) decreases a(HM:"erythrocyte-endothelium adhesion") View Subject | View Object

HRG treatment significantly inhibited the attachment of erythrocytes to the vascular endothelial cell monolayer in a concentration dependent manner (Fig. 4A and B), while HSA did not affect the adhesion. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

deg(p(HGNC:HRG)) positiveCorrelation p(HGNC:F2) View Subject | View Object

The decrease was due to the reduction in HRG gene expression, deposition of HRG on immunothrombi and degradation of HRG by thrombin. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.