bp(MESH:"Erythrocyte Aggregation")
Stimulation with 20 mM Zn2þ resulted in aggregation of washed human erythrocytes 1 h after incubation. PubMed:29544683
Thus focusing on Zn2þ-stimulated erythrocytes might be an important new approach that could ultimately reveal the mechanism of immunothrombus formation in sepsis. PubMed:29544683
At low shear rates or with stasis of blood, RBCs tend to form linear arrays of stacked cells (roleaux) or three-dimensional aggregates [16]. PubMed:28458720
Although neutrophils, platelets and vascular endothelial cells are the main effector cells involved in immunothrombosis, abnormal aggregation of erythrocytes under septic conditions may also contribute to immunothrombosis in sepsis. PubMed:29544683
An increase of fibrinogen concentration can result in greater RBC aggregation, which is associated with a higher incidence of thrombosis. PubMed:28458720
HRG strongly inhibited the aggregation at a concentration of 1 mg/mL, whereas the same concentration of HSA showed no effect (Fig. 1B). PubMed:29544683
HRG and HSA both strongly inhibited aggregation when the concentration was increased to 100 mg/mL (Supplementary Fig. 1). PubMed:29544683
Annexin V (100 nM) completely inhibited the Zn2þ-induced aggregation (Fig. 1E). PubMed:29544683
HRG strongly inhibited the aggregation at a concentration of 1 mg/mL, whereas the same concentration of HSA showed no effect (Fig. 1B). PubMed:29544683
HRG and HSA both strongly inhibited aggregation when the concentration was increased to 100 mg/mL (Supplementary Fig. 1). PubMed:29544683
An increase of fibrinogen concentration can result in greater RBC aggregation, which is associated with a higher incidence of thrombosis. PubMed:28458720
Another consequence of the axial RBC accumulation followed by reduction in local viscosity is a decrease of the wall shear stress causing a lesser local release of nitric oxide [15]. PubMed:28458720
Such aggregates are difficult to disperse and they tend to increase the blood viscosity and hydrodynamic resistance in larger blood vessels with low shear, such as the veins in the lower limbs. PubMed:28458720
Another consequence of the axial RBC accumulation followed by reduction in local viscosity is a decrease of the wall shear stress causing a lesser local release of nitric oxide [15]. PubMed:28458720
At low shear rates or with stasis of blood, RBCs tend to form linear arrays of stacked cells (roleaux) or three-dimensional aggregates [16]. PubMed:28458720
RBC aggregation promotes thrombosis in veins, confirming the pathogenic importance of locally altered blood rheology in the development of venous thrombosis [17]. PubMed:28458720
An increase of fibrinogen concentration can result in greater RBC aggregation, which is associated with a higher incidence of thrombosis. PubMed:28458720
RBC aggregation promotes thrombosis in veins, confirming the pathogenic importance of locally altered blood rheology in the development of venous thrombosis [17]. PubMed:28458720
Although neutrophils, platelets and vascular endothelial cells are the main effector cells involved in immunothrombosis, abnormal aggregation of erythrocytes under septic conditions may also contribute to immunothrombosis in sepsis. PubMed:29544683
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.