bp(GO:"erythrocyte apoptotic process")
In Ko + Pb mice, apoptotic cells were increased by a greater degree, 79.4% in BM erythrocytes, compared to those in Ko − Pb mice (Figure 7B; P = 0.012). PubMed:25411909
Apoptosis of splenic erythrocytes in Ko + Pb mice was enhanced by 19.0%, compared to that in Ko − Pb mice and by 55.4% in comparison to that in Wt + Pb mice (Figure 7C; P = 0.019). PubMed:25411909
These data suggested that Pb-induced anemia should be ascribed to (at least partially) Pbinduced death of erythrocytes, and also stressed the critical role of Hri in assuring the survival of BM and spleen erythroid cells under Pb exposure. PubMed:25411909
Hri is activated to protect cells from oxidative stress-provoked apoptosis upon arsenic, cadmium, and iron deficiency.18,19,22 PubMed:25411909
In Ko + Pb mice, apoptotic cells were increased by a greater degree, 79.4% in BM erythrocytes, compared to those in Ko − Pb mice (Figure 7B; P = 0.012). PubMed:25411909
Apoptosis of splenic erythrocytes in Ko + Pb mice was enhanced by 19.0%, compared to that in Ko − Pb mice and by 55.4% in comparison to that in Wt + Pb mice (Figure 7C; P = 0.019). PubMed:25411909
These data suggested that Pb-induced anemia should be ascribed to (at least partially) Pbinduced death of erythrocytes, and also stressed the critical role of Hri in assuring the survival of BM and spleen erythroid cells under Pb exposure. PubMed:25411909
Hri is activated to protect cells from oxidative stress-provoked apoptosis upon arsenic, cadmium, and iron deficiency.18,19,22 PubMed:25411909
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.