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p(MGI:Lamp1)

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Entity

Name
Lamp1
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading v1.0.0

In-Edges 2

p(MGI:Tfeb) increases p(MGI:Lamp1) View Subject | View Object

as expected, the expression of several TFEB lysosomal target genes was signifi- cantly up-regulated in TFEB-transduced astrocytes, including lysosomal marker LAMP1 and lysosomal proteases, cathepsins A and B PubMed:30108137

Appears in Networks:

path(MESH:Tauopathies) increases p(MGI:Lamp1) View Subject | View Object

Examining the protein levels in another tauopathy mouse model, hippocampal lysates from PS19 mice (Yoshiyama et al., 2007) at 10 mo of age showed increases in TFEB and lysosomal proteins LAMP1 and CTSD com- pared with wild-type mice (Fig. S1, G and H). PubMed:30108137

Appears in Networks:

Out-Edges 0

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.