1. Catalog
  2. Nodes
  3. a(CHEBI:ibuprofen)

a(CHEBI:ibuprofen)

Equivalencies: 0 | Classes: 2 | Children: 0 | Explore

Entity

Name
ibuprofen
Namespace
chebi
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/chebi-names.belns

Appears in Networks 2

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. v1.0.0

Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0

In-Edges 0

Out-Edges 5

a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") View Subject | View Object

Appears in Networks:

a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) View Subject | View Object

Consistent with pB1P-N1 plasmid results, TNF-a significantly induced BACE1-NF-kB promoter activation (p<0.005) and the NSAIDs aspirin, ibuprofen and indomethacin significantly blocked the TNF-a-induced BACE1- NF-kB promoter activation (p<0.005) (Fig. 6b). PubMed:21329555

Appears in Networks:

a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") View Subject | View Object

Appears in Networks:

a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) View Subject | View Object

Further- more, naproxen and ibuprofen and perhaps other NSAIDs, can block the inflammation-induced BACE1 transcription and Aβ production [52,87]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus

a(CHEBI:ibuprofen) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

Further- more, naproxen and ibuprofen and perhaps other NSAIDs, can block the inflammation-induced BACE1 transcription and Aβ production [52,87]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.