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p(FPLX:AMPK, pmod(Ph, Thr, 172))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
AMPK
Namespace
FPLX
Namespace Version
20190217
Namespace URL
https://raw.githubusercontent.com/sorgerlab/famplex/d9ec0526c20795146a9a6aef17496efe1a36cac6/export/famplex.belns

Appears in Networks 1

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

In-Edges 2

composite(a(CHEBI:"calcium(2+)"), p(HGNC:CAMKK2)) increases p(FPLX:AMPK, pmod(Ph, Thr, 172)) View Subject | View Object

The ‘anti-ageing’ agent resveratrol is thought to indi- rectly recruit AMPK via activation of calcium/calmodulin- dependent protein kinase kinase 2 (CAMKK2), which, acting in synergy with Ca 2+ , exerts its effects via Thr172 phosphorylation 113 . This action, among others (below), is involved in its reduction of Aβ levels in N2a cells and neurons 114 and the elimination of Aβ and Htt in animal models of AD and HD 114,115 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

p(FPLX:AMPK) hasVariant p(FPLX:AMPK, pmod(Ph, Thr, 172)) View Subject | View Object

Appears in Networks:

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.