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Entity

Name
Presynaptic Terminals
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 2

In-Edges 0

Out-Edges 2

a(MESH:"Presynaptic Terminals") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) View Subject | View Object

The ‘‘volume transmission’’ hypothesis states that ACh released from presynaptic terminals spreads to more distant areas, reaching concentrations < 1 mM (Descarries et al., 1997), but that multiple presynaptic impulses produce enough summed release to activate receptors (Lester, 2004) PubMed:21482353

a(MESH:"Presynaptic Terminals") causesNoChange p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

The axons of transfected neurons (Fig. 1 G and I) clearly reveal small inclusions of Tau (∼1 μm in size, arrowheads), although presynaptic boutons (e.g., giant mossy fiber boutons) are only marginally stained for Tau (Fig. 1I and Fig. S2 A and B; arrow), indicating that Tau does not accumulate at presynaptic boutons in these slices PubMed:27671637

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.