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complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT))

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Components

Appears in Networks 1

Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers v1.0.0

In-Edges 2

a(HBP:"amyloid-beta oligomers") decreases complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) View Subject | View Object

When we investigated Abetao-driven tau translocation to the synapse, we did not see any change in half-life recovery (4.729 s) from those measured with synaptic activation. However, the plateau value was drastically modified (71.20%), illustrating that, whereas Abetao induced tau translocation and subsequently its interaction with actin filament, the resulting synaptic tau is less stable. PubMed:24760868

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Results

a(MESH:"Dendritic Spines") association complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) View Subject | View Object

The recovery curves indicated 3 pools of tau: a mobile, unbleached fraction comprising 9.72  1.03%, a dynamic fraction at 47.08  3.06%, and a stable, unrecoverable fraction at 42.75  2.78%. This stable fraction suggests that a large portion of tau is anchored in the spine. PubMed:24760868

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Out-Edges 3

complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) hasComponent a(MESH:"Dendritic Spines") View Subject | View Object

Appears in Networks:

complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) association a(MESH:"Dendritic Spines") View Subject | View Object

The recovery curves indicated 3 pools of tau: a mobile, unbleached fraction comprising 9.72  1.03%, a dynamic fraction at 47.08  3.06%, and a stable, unrecoverable fraction at 42.75  2.78%. This stable fraction suggests that a large portion of tau is anchored in the spine. PubMed:24760868

Appears in Networks:
Annotations
Text Location
Results

complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) hasComponent p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.