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bp(HBP:"protein aggregation")

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Entity

Name
protein aggregation
Namespace
HBP
Namespace Version
20190126
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/77c0796c3ca82a80cb0eaf1c8380d6ccd7f323af/export/hbp-names.belns

Appears in Networks 1

Perilous journey: a tour of the ubiquitin–proteasome system v1.0.0

In-Edges 3

complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) decreases bp(HBP:"protein aggregation") View Subject | View Object

Because Bag6 interacts with both E3 ligases as well as the proteasome [57,58,60], it may promote both the ubiquitination and delivery of misfolded proteins to the proteasome while preventing their aggregation PubMed:24457024

Appears in Networks:

p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(HBP:"protein aggregation") View Subject | View Object

Misfolded proteins can aggregate with time, and protein quality-control pathways are tasked with their ubiquitination and subsequent degradation [46,47]. PubMed:24457024

Appears in Networks:

complex(p(HGNC:BAG6), p(HGNC:UBA3)) decreases bp(HBP:"protein aggregation") View Subject | View Object

Because Bag6 interacts with both E3 ligases as well as the proteasome [57,58,60], it may promote both the ubiquitination and delivery of misfolded proteins to the proteasome while preventing their aggregation PubMed:24457024

Appears in Networks:

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.