p(HGNC:BAG3)

Entity

Name

BAG3

Namespace

hgnc

Namespace Version

20180906

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Proteasome inhibitors and trehalose increase autophagy and decrease tau content by up-regulating the expression of cochaperone BAG3 targeting tau to the autophagy pathway for degradation (Lei et al. 2015) PubMed:29626319

Proteasome inhibitors and trehalose increase autophagy and decrease tau content by up-regulating the expression of cochaperone BAG3 targeting tau to the autophagy pathway for degradation (Lei et al. 2015) PubMed:29626319

As previously reported (Fuchs et al., 2010), BAG3 associated with the small heat shock proteins Hsp22/HSPB8 and Hsp27/HSPB1. In addition, we detected a robust interaction with HSF1, the master regulator of the heat-shock response (Figure 3E) PubMed:25036637

As previously reported (Fuchs et al., 2010), BAG3 associated with the small heat shock proteins Hsp22/HSPB8 and Hsp27/HSPB1. In addition, we detected a robust interaction with HSF1, the master regulator of the heat-shock response (Figure 3E) PubMed:25036637

BAG3 and BAG4 showed a strong association only with the small heat shock protein Hsp27 (Figure 5F) and the mRNA decapping complex member DCP1B, respectively (Figure 5G), whereas BAG1 interacted with several proteasome subunits (Figure S4C) PubMed:25036637

As previously reported (Fuchs et al., 2010), BAG3 associated with the small heat shock proteins Hsp22/HSPB8 and Hsp27/HSPB1. In addition, we detected a robust interaction with HSF1, the master regulator of the heat-shock response (Figure 3E) PubMed:25036637

BAG3 and BAG4 showed a strong association only with the small heat shock protein Hsp27 (Figure 5F) and the mRNA decapping complex member DCP1B, respectively (Figure 5G), whereas BAG1 interacted with several proteasome subunits (Figure S4C) PubMed:25036637

Proteasome inhibitors and trehalose increase autophagy and decrease tau content by up-regulating the expression of cochaperone BAG3 targeting tau to the autophagy pathway for degradation (Lei et al. 2015) PubMed:29626319

BAG1 targets proteins for degradation by the UPS, whereas BAG3 mediates degradation by macroautophagy. PubMed:23746257