D016874

In-Edges 3

path(MESH:D000544) association path(MESH:D016874) View Subject | View Object

From the perspective of brain histopathology, Alzheimer's disease has three characteristic features—the appearance of beta-amyloid plaques, the presence of neurofibrillary tangles, and the loss of neuronal cells PubMed:16273023

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Interplay of neurotransmitters in Alzheimer's disease v1.0.0

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Disease Ontology (DO): Alzheimer's disease

bp(HBP:hyperphosphorylation) association path(MESH:D016874) View Subject | View Object

In addition, subunits of protein phosphatase PP1 (Unigene-NCBI annotation PPP1CA and PPP1CC) mRNAs were downregulated in CBF neurons in AD [135]. This observation is interesting in light of the observation that PP1 can phosphorylate tau on several serine/threonine residues and experimental downregulation of PP1 activity leads to increased tau hyperphosphorylation [137,138], which may affect NFT formation in CBF neurons. PubMed:18986241

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Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

Annotations

Disease Ontology (DO): Alzheimer's disease
MeSH: Cholinergic Neurons
MeSH: Cognitive Dysfunction

path(MESH:D000544) increases path(MESH:D016874) View Subject | View Object

Cortical and CBF neurons display NFT formation in the MCI brain [9,139,140], suggesting a concomitant alteration in tau gene expression during the early stage of AD. The adult human brain contains six tau isoforms ranging from 48 to 67 kDa, which are expressed through alternative splicing of a single tau gene on chromosome 17 [141,142]. Three of these tau isoforms contain three tandem repeats in the carboxy-terminus end of the molecule (3Rtau), while three isoforms display four tandem repeats (4Rtau) in this region. Expression levels of the six tau transcripts within CBF neurons do not differ significantly during the progression of AD [6] PubMed:18986241