path(MESH:Necrosis)
NFT containing neurons upregulated genes involved in cell survival and viability, inflammation, cell cycle progression and molecular transport and downregulated apoptosis, necrosis and cell death pathways (Figure 1a). NFkB, a pro-survival master transcriptional regulator of inflammation, was the highest predicted upstream regulator of the NFT-gene expression profile. In agreement with inflammatory activation, other predicted upstream regulators included IFNG, TNF, TLR4, IL1B and CXCL1 (Figure 1b) PubMed:30126037
Cataclysmic disruption of lysosomal membranes releases hydrolases that act as both the trigger and executioner in rapid necrosis (Syntichaki et al. 2003; Kroemer et al. 2005), whereas slow release of cathepsins more likely operates through signaling pathways to trigger apoptosis (Kroemer et al. 2005). PubMed:22908190
Podocyte necrosis was also frequently observed, leading to impaired glomerular barrier morphology with large basement membrane fenestrations (Figure 7B, arrowheads). Similar phenomena were observed in proximal tubules where starvation induced tubular damage with cell necrosis and an overall disturbed tubular morphology (Figure 7A, middle panel). These overall effects were reversed by A1M (Figure 7 A and B, lower panels). PubMed:24489717
Podocyte necrosis was also frequently observed, leading to impaired glomerular barrier morphology with large basement membrane fenestrations (Figure 7B, arrowheads). Similar phenomena were observed in proximal tubules where starvation induced tubular damage with cell necrosis and an overall disturbed tubular morphology (Figure 7A, middle panel). These overall effects were reversed by A1M (Figure 7 A and B, lower panels). PubMed:24489717
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.