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path(HP:"Arterial occlusion")

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Entity

Name
Arterial occlusion
Namespace
HP
Namespace Version
2017-10-05
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hp/hp-20171108.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

bp(HM:"Monocyte-platelet aggregation") positiveCorrelation path(HP:"Arterial occlusion") View Subject | View Object

Although aggregation has not been investigated in PNH, we clearly show here that in primary Cys89Tyr CD59 mutation there is a significant increase in coaggregation with high numbers of activated platelets adhering to a single monocyte, and granulocytes to monocytes, that may lead to nonendothelial-bound arterial occlusion, among other effects [36]. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

Out-Edges 1

path(HP:"Arterial occlusion") positiveCorrelation bp(HM:"Monocyte-platelet aggregation") View Subject | View Object

Although aggregation has not been investigated in PNH, we clearly show here that in primary Cys89Tyr CD59 mutation there is a significant increase in coaggregation with high numbers of activated platelets adhering to a single monocyte, and granulocytes to monocytes, that may lead to nonendothelial-bound arterial occlusion, among other effects [36]. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.