1. Catalog
  2. Nodes
  3. p(HGNC:MAPT, frag("292_319"))

p(HGNC:MAPT, frag("292_319"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau v1.0.0

In-Edges 2

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, frag("292_319")) View Subject | View Object

Appears in Networks:

complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("292_319"))) hasComponent p(HGNC:MAPT, frag("292_319")) View Subject | View Object

Appears in Networks:

Out-Edges 1

p(HGNC:MAPT, frag("292_319")) increases bp(GO:"actin filament bundle assembly") View Subject | View Object

Tau(292–319) comprises the residues of repeat R2 and R3, which experience strong signal attenuation upon addition of F-actin to full-length Tau (Fig. 1e, f). In agreement with the ability of Tau(292–319) to bind to F-actin, the peptide promotes bundling of actin filaments (Supplementary Fig. 5c) PubMed:29215007

Appears in Networks:
Annotations
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.