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p(CHEBI:"amyloid-beta")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
amyloid-beta
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Clearance systems in the brain-implications for Alzheimer disease. v1.0.1

In-Edges 3

a(MESH:"Blood-Brain Barrier") decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) View Subject | View Object

In the early 2000s, mouse studies demonstrated that the majority (75%) of extracellular Aβ (eAβ) is cleared by the BBB, with only a minority (10%) being cleared by ISF bulk flow. PubMed:26195256

Appears in Networks:

a(MESH:"Extracellular Fluid") decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) View Subject | View Object

In the early 2000s, mouse studies demonstrated that the majority (75%) of extracellular Aβ (eAβ) is cleared by the BBB, with only a minority (10%) being cleared by ISF bulk flow. PubMed:26195256

Appears in Networks:

act(p(HGNC:AQP4)) decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) View Subject | View Object

However, two-photon imaging studies from the past few years have suggested that ISF bulk flow—facilitated by astroglial aquaporin-4 (AQP4) channels and named the glymphatic (glial + lymphatic) system—contributes to a larger portion of eAβ clearance than previously thought. PubMed:26195256

Appears in Networks:

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.