Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Blood-Brain Barrier
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 3

In-Edges 5

p(HBP:"APOE e4") regulates a(MESH:"Blood-Brain Barrier") View Subject | View Object

Third, ApoE4 is also associated with lower antioxidant activity than other ApoE isoforms,154,155 and it mediates BBB breakdown through a proinflammatory pathway involving cyclophilin A in pericytes. PubMed:26195256

p(HGNC:PPIA) association act(a(MESH:"Blood-Brain Barrier")) View Subject | View Object

Third, ApoE4 is also associated with lower antioxidant activity than other ApoE isoforms,154,155 and it mediates BBB breakdown through a proinflammatory pathway involving cyclophilin A in pericytes. PubMed:26195256

path(MESH:Sleep) increases act(a(MESH:"Blood-Brain Barrier")) View Subject | View Object

Thus, sleep could indirectly increase BBB clearance of Aβ through increased glymphatic bulk flow, but it might also directly increase clearance through the BBB via various mechanisms, such as molecular changes (for example, upregulated LRP1), as seen with AD-protective physical and cognitive activity in mice.1 PubMed:26195256

p(HGNC:SLC2A1) regulates a(MESH:"Blood-Brain Barrier") View Subject | View Object

In addition, the transport of GLUT1-mediated glucose into the brain is also beneficial to maintaining the integrity of the BBB, thereby ensuring the normal transport of Aβ from brain into blood (Winkler et al. 2015) PubMed:29626319

a(CHEBI:chlorobutanol) causesNoChange a(MESH:"Blood-Brain Barrier") View Subject | View Object

These findings provide clear evidence that the blood brain barrier remained intact in the presence of chlorobutanol PubMed:30664622

Out-Edges 2

a(MESH:"Blood-Brain Barrier") decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) View Subject | View Object

In the early 2000s, mouse studies demonstrated that the majority (75%) of extracellular Aβ (eAβ) is cleared by the BBB, with only a minority (10%) being cleared by ISF bulk flow. PubMed:26195256

act(a(MESH:"Blood-Brain Barrier")) association p(HGNC:PPIA) View Subject | View Object

Third, ApoE4 is also associated with lower antioxidant activity than other ApoE isoforms,154,155 and it mediates BBB breakdown through a proinflammatory pathway involving cyclophilin A in pericytes. PubMed:26195256

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.