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Appears in Networks 2

In-Edges 4

bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:HTT, frag("?"))) View Subject | View Object

This indicates that the truncated fragments are normally processed via the UPS, and therefore the disposal of fragments of mutant proteins will be impaired. PubMed:14556719

act(complex(GO:"proteasome complex")) decreases p(HGNC:HTT, frag("?")) View Subject | View Object

Lunkes and colleagues demonstrated that truncated Huntingtin, which has undergone proteolytic cleavage in the cytoplasm, accumulates more rapidly if the proteasome is pharmacologically inhibited (Lunkes et al., 2002). PubMed:14556719

p(HGNC:MMP9) increases p(HGNC:HTT, frag("?")) View Subject | View Object

MMP-9 directly cleaves Huntingtin protein in Huntington’s disease, a progressive neurodegenerative disorder (Miller et al., 2010) PubMed:27594586

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.