p(HGNC:HTT, frag("?"))
This indicates that the truncated fragments are normally processed via the UPS, and therefore the disposal of fragments of mutant proteins will be impaired. PubMed:14556719
Lunkes and colleagues demonstrated that truncated Huntingtin, which has undergone proteolytic cleavage in the cytoplasm, accumulates more rapidly if the proteasome is pharmacologically inhibited (Lunkes et al., 2002). PubMed:14556719
MMP-9 directly cleaves Huntingtin protein in Huntington’s disease, a progressive neurodegenerative disorder (Miller et al., 2010) PubMed:27594586
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.