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p(HGNC:HTT)

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Entity

Name
HTT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 5

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Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

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In-Edges 7

complex(p(HGNC:HTT), p(HGNC:UBA2)) hasComponent p(HGNC:HTT) View Subject | View Object

Appears in Networks:

a(CHEBI:"lithium(1+)") decreases p(HGNC:HTT) View Subject | View Object

This mechanism may be involved in its promotion of autophagy, reduction in cel- lular levels of α-synuclein, SOD1, Htt and tau 126 , ame- lioration of motor function in a P301L mouse model of tauopathy 127 and slowing of disease progression in SOD1 mice 128 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

a(CHEBI:Rilmenidine) increases deg(p(HGNC:HTT)) View Subject | View Object

Indeed, clonidine and rilmenidine, two G i /G o -coupled α 2 -adrenergic receptor and imidazoline 1 receptor agonists, stimulate autophagy and cleared Htt in cellular 103 and animal models of HD 104 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Huntington Disease

a(CHEBI:clonidine) increases deg(p(HGNC:HTT)) View Subject | View Object

Indeed, clonidine and rilmenidine, two G i /G o -coupled α 2 -adrenergic receptor and imidazoline 1 receptor agonists, stimulate autophagy and cleared Htt in cellular 103 and animal models of HD 104 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Huntington Disease

a(CHEBI:resveratrol) decreases p(HGNC:HTT) View Subject | View Object

The ‘anti-ageing’ agent resveratrol is thought to indi- rectly recruit AMPK via activation of calcium/calmodulin- dependent protein kinase kinase 2 (CAMKK2), which, acting in synergy with Ca 2+ , exerts its effects via Thr172 phosphorylation 113 . This action, among others (below), is involved in its reduction of Aβ levels in N2a cells and neurons 114 and the elimination of Aβ and Htt in animal models of AD and HD 114,115 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

a(CHEBI:sirolimus) decreases p(HGNC:HTT) View Subject | View Object

Enhancing auto- phagy with rapamycin reduced levels of α-synuclein, FUS and Htt 130–132 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT)) View Subject | View Object

Htt is not efficiently cleared by CMA, and the same appears to hold for its fragments and mutant and post- translationally modified forms, although the precise role of CMA in Htt elimination remains to be more fully defined 2,45–47 . PubMed:30116051

Appears in Networks:

Out-Edges 6

p(HGNC:HTT) hasVariant p(HGNC:HTT, frag("?")) View Subject | View Object

Appears in Networks:

p(HGNC:HTT) hasVariant p(HGNC:HTT, pmod(Ub)) View Subject | View Object

Appears in Networks:

p(HGNC:HTT) hasVariant p(HGNC:HTT, var("?")) View Subject | View Object

Appears in Networks:

p(HGNC:HTT) increases complex(p(HGNC:HTT), p(HGNC:UBA2)) View Subject | View Object

Thus,Huntingtin was found to be ubiquitinated and also to interact with E2-25 kDa (Kalchman et al., 1996). PubMed:14556719

Appears in Networks:

p(HGNC:HTT) decreases act(complex(GO:"proteasome complex")) View Subject | View Object

In a cell culture model, they overexpressed mutant Huntingtin and observed proteasomal inhibition accompanied by cell cycle arrest PubMed:14556719

Appears in Networks:

p(HGNC:HTT) increases bp(GO:"cell cycle arrest") View Subject | View Object

In a cell culture model, they overexpressed mutant Huntingtin and observed proteasomal inhibition accompanied by cell cycle arrest PubMed:14556719

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.