complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 2

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

In-Edges 0

Out-Edges 3

complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) hasComponent a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) hasComponent p(HGNC:APP) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) regulates bp(HBP:HBP00073) View Subject | View Object

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011) PubMed:22122372

Appears in Networks:

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

Annotations

Confidence: High
MeSH: Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.