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Appears in Networks 4

In-Edges 13

p(HGNC:APBA1) regulates bp(HBP:HBP00073) View Subject | View Object

Overexpression of Mint1, Mint2, or Fe65 causes reduction in Aβ generation and deposition in the brains of transgenic mice, strongly suggesting a physiological role for these adaptors in regulating APP processing in the nervous tis- sue (17). PubMed:18650430

p(HGNC:APBA2) regulates bp(HBP:HBP00073) View Subject | View Object

Overexpression of Mint1, Mint2, or Fe65 causes reduction in Aβ generation and deposition in the brains of transgenic mice, strongly suggesting a physiological role for these adaptors in regulating APP processing in the nervous tis- sue (17). PubMed:18650430

p(HGNC:APBB1) regulates bp(HBP:HBP00073) View Subject | View Object

Overexpression of Mint1, Mint2, or Fe65 causes reduction in Aβ generation and deposition in the brains of transgenic mice, strongly suggesting a physiological role for these adaptors in regulating APP processing in the nervous tis- sue (17). PubMed:18650430

p(HGNC:RAB6A) association bp(HBP:HBP00073) View Subject | View Object

Rab6, a member of the GTP-binding protein family of membrane trafficking regulators, is implicated in protein transport along biosynthetic and endocytic pathways and has also been found to affect APP processing PubMed:21214928

complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) regulates bp(HBP:HBP00073) View Subject | View Object

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011) PubMed:22122372

complex(p(HGNC:APP), p(HGNC:ITM2B)) regulates bp(HBP:HBP00073) View Subject | View Object

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011) PubMed:22122372

complex(p(HGNC:APP), p(HGNC:NTN1)) regulates bp(HBP:HBP00073) View Subject | View Object

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011) PubMed:22122372

complex(p(HGNC:APP), p(HGNC:RTN4R)) regulates bp(HBP:HBP00073) View Subject | View Object

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011) PubMed:22122372

complex(p(HGNC:APP), p(HGNC:SPON1)) regulates bp(HBP:HBP00073) View Subject | View Object

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011) PubMed:22122372

p(HBP:HBP00071, pmod(Ph, Ser, 665)) association bp(HBP:HBP00073) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

p(HBP:HBP00071, pmod(Ph, Thr, 654)) association bp(HBP:HBP00073) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

p(HBP:HBP00071, pmod(Ph, Thr, 668)) association bp(HBP:HBP00073) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

p(HGNC:LRRK2, var("?")) association bp(HBP:HBP00073) View Subject | View Object

Some of these lead to an impairment of the ALN owing to reduced activation of beclin 1; another repercussion may be altered process- ing of APP, providing an unexpected link to AD 69,71–73 . PubMed:30116051

Out-Edges 5

bp(HBP:HBP00073) association p(HGNC:RAB6A) View Subject | View Object

Rab6, a member of the GTP-binding protein family of membrane trafficking regulators, is implicated in protein transport along biosynthetic and endocytic pathways and has also been found to affect APP processing PubMed:21214928

bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

bp(HBP:HBP00073) association p(HGNC:LRRK2, var("?")) View Subject | View Object

Some of these lead to an impairment of the ALN owing to reduced activation of beclin 1; another repercussion may be altered process- ing of APP, providing an unexpected link to AD 69,71–73 . PubMed:30116051

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.