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p(HGNC:LRRK2, var("?"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
LRRK2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases v1.0.0

In-Edges 3

bp(HBP:HBP00073) association p(HGNC:LRRK2, var("?")) View Subject | View Object

Some of these lead to an impairment of the ALN owing to reduced activation of beclin 1; another repercussion may be altered process- ing of APP, providing an unexpected link to AD 69,71–73 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:LRRK2) hasVariant p(HGNC:LRRK2, var("?")) View Subject | View Object

Appears in Networks:

path(MESH:"Parkinson Disease") association p(HGNC:LRRK2, var("?")) View Subject | View Object

Second, the GTPase leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) is the most commonly mutated protein in late-onset, familial PD. PubMed:30116051

Appears in Networks:
Annotations
MeSH
Parkinson Disease

Out-Edges 6

p(HGNC:LRRK2, var("?")) association path(MESH:"Parkinson Disease") View Subject | View Object

Second, the GTPase leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) is the most commonly mutated protein in late-onset, familial PD. PubMed:30116051

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:LRRK2, var("?")) decreases bp(GO:autophagy) View Subject | View Object

Some of these lead to an impairment of the ALN owing to reduced activation of beclin 1; another repercussion may be altered process- ing of APP, providing an unexpected link to AD 69,71–73 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:LRRK2, var("?")) decreases act(p(HGNC:BECN1)) View Subject | View Object

Some of these lead to an impairment of the ALN owing to reduced activation of beclin 1; another repercussion may be altered process- ing of APP, providing an unexpected link to AD 69,71–73 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:LRRK2, var("?")) association bp(HBP:HBP00073) View Subject | View Object

Some of these lead to an impairment of the ALN owing to reduced activation of beclin 1; another repercussion may be altered process- ing of APP, providing an unexpected link to AD 69,71–73 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:LRRK2, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") View Subject | View Object

In addition, CMA is disrupted by sev- eral genetic mutations occurring in PD, including muta- tions in LRRK2 (REFS2,3,45–47,55,69,80) . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Parkinson Disease

p(HGNC:LRRK2, var("?")) increases bp(GO:"neuron death") View Subject | View Object

The expression of LRRK2 mutants can cause apoptosis of neuronal and neuroblastoma cells PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.