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p(HGNC:LRRK2)

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Entity

Name
LRRK2
Namespace
hgnc
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/hgnc-symbols.belns

Appears in Networks 4

Alpha-synuclein oligomers: a new hope v1.0.0

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases v1.0.0

In-Edges 4

path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:LRRK2) View Subject | View Object

Using mass spectrometry, we identified multiple sites on recombinant tau that are phosphorylated by LRRK2 in vitro, including pT149 and pT153, which are phospho-epitopes that to date have been largely unexplored. Importantly, we demonstrate that expression of transgenic LRRK2 in a mouse model of tauopathy increased the aggregation of insoluble tau and its phosphorylation at T149, T153, T205, and S199/S202/T205 epitopes. PubMed:24113872

Appears in Networks:

g(HGNC:MIR205) regulates p(HGNC:LRRK2) View Subject | View Object

It has also been shown that miR‐205 can regulate LRRK2 and that PD is associated with a significant reduction in the level of miR‐205 in the frontal cortex and striatum PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

g(HGNC:MIR205) regulates p(HGNC:LRRK2) View Subject | View Object

Expression of miR‐205 affects the level of LRRK2 expression, and LRRK2, in turn, affects two miRNAs called let‐7 and miR‐184. This effect is associated with decreased activity and level of let‐7 and miR‐184 within the cell PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

path(MESH:"Parkinson Disease") association p(HGNC:LRRK2) View Subject | View Object

One of the most important proteins involved in PD is the LRRK2 protein PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

Out-Edges 13

p(HGNC:LRRK2) hasVariant p(HGNC:LRRK2, var("p.Gly2019Ser")) View Subject | View Object

Appears in Networks:

p(HGNC:LRRK2) hasVariant p(HGNC:LRRK2, var("?")) View Subject | View Object

Appears in Networks:

p(HGNC:LRRK2) positiveCorrelation path(MESH:"Parkinson Disease") View Subject | View Object

Using mass spectrometry, we identified multiple sites on recombinant tau that are phosphorylated by LRRK2 in vitro, including pT149 and pT153, which are phospho-epitopes that to date have been largely unexplored. Importantly, we demonstrate that expression of transgenic LRRK2 in a mouse model of tauopathy increased the aggregation of insoluble tau and its phosphorylation at T149, T153, T205, and S199/S202/T205 epitopes. PubMed:24113872

Appears in Networks:

act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 149)) View Subject | View Object

Using mass spectrometry, we identified multiple sites on recombinant tau that are phosphorylated by LRRK2 in vitro, including pT149 and pT153, which are phospho-epitopes that to date have been largely unexplored. Importantly, we demonstrate that expression of transgenic LRRK2 in a mouse model of tauopathy increased the aggregation of insoluble tau and its phosphorylation at T149, T153, T205, and S199/S202/T205 epitopes. PubMed:24113872

Appears in Networks:

act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 153)) View Subject | View Object

Using mass spectrometry, we identified multiple sites on recombinant tau that are phosphorylated by LRRK2 in vitro, including pT149 and pT153, which are phospho-epitopes that to date have been largely unexplored. Importantly, we demonstrate that expression of transgenic LRRK2 in a mouse model of tauopathy increased the aggregation of insoluble tau and its phosphorylation at T149, T153, T205, and S199/S202/T205 epitopes. PubMed:24113872

Appears in Networks:

act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) View Subject | View Object

Using mass spectrometry, we identified multiple sites on recombinant tau that are phosphorylated by LRRK2 in vitro, including pT149 and pT153, which are phospho-epitopes that to date have been largely unexplored. Importantly, we demonstrate that expression of transgenic LRRK2 in a mouse model of tauopathy increased the aggregation of insoluble tau and its phosphorylation at T149, T153, T205, and S199/S202/T205 epitopes. PubMed:24113872

Appears in Networks:

act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau epitope, AT8") View Subject | View Object

Using mass spectrometry, we identified multiple sites on recombinant tau that are phosphorylated by LRRK2 in vitro, including pT149 and pT153, which are phospho-epitopes that to date have been largely unexplored. Importantly, we demonstrate that expression of transgenic LRRK2 in a mouse model of tauopathy increased the aggregation of insoluble tau and its phosphorylation at T149, T153, T205, and S199/S202/T205 epitopes. PubMed:24113872

Appears in Networks:

act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau aggregates") View Subject | View Object

Using mass spectrometry, we identified multiple sites on recombinant tau that are phosphorylated by LRRK2 in vitro, including pT149 and pT153, which are phospho-epitopes that to date have been largely unexplored. Importantly, we demonstrate that expression of transgenic LRRK2 in a mouse model of tauopathy increased the aggregation of insoluble tau and its phosphorylation at T149, T153, T205, and S199/S202/T205 epitopes. PubMed:24113872

Appears in Networks:

p(HGNC:LRRK2) association path(MESH:"Parkinson Disease") View Subject | View Object

One of the most important proteins involved in PD is the LRRK2 protein PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:LRRK2) decreases g(HGNC:MIRLET7A1) View Subject | View Object

Expression of miR‐205 affects the level of LRRK2 expression, and LRRK2, in turn, affects two miRNAs called let‐7 and miR‐184. This effect is associated with decreased activity and level of let‐7 and miR‐184 within the cell PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:LRRK2) decreases act(g(HGNC:MIRLET7A1)) View Subject | View Object

Expression of miR‐205 affects the level of LRRK2 expression, and LRRK2, in turn, affects two miRNAs called let‐7 and miR‐184. This effect is associated with decreased activity and level of let‐7 and miR‐184 within the cell PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:LRRK2) decreases g(HGNC:MIR184) View Subject | View Object

Expression of miR‐205 affects the level of LRRK2 expression, and LRRK2, in turn, affects two miRNAs called let‐7 and miR‐184. This effect is associated with decreased activity and level of let‐7 and miR‐184 within the cell PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:LRRK2) decreases act(g(HGNC:MIR184)) View Subject | View Object

Expression of miR‐205 affects the level of LRRK2 expression, and LRRK2, in turn, affects two miRNAs called let‐7 and miR‐184. This effect is associated with decreased activity and level of let‐7 and miR‐184 within the cell PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.