1. Catalog
  2. Nodes
  3. p(HGNC:CAPN2)

p(HGNC:CAPN2)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CAPN2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

In-Edges 5

a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN2)) View Subject | View Object

Calpeptin, a cell-permeable calpain inhibitor, can also reduce Htt proteinopathy via induction of autophagy 103,105 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Huntington Disease

p(HGNC:CAST) decreases act(p(HGNC:CAPN2)) View Subject | View Object

Genetic knockdown of calpain 1 or calpain 2 or overexpression of their endogenous inhibitor, calpastatin, increased autophagy and cleared aggregates in SK-N-SH cells overexpressing a mutant form of Htt 103 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Huntington Disease

p(HGNCGENEFAMILY:Calpains) hasMember p(HGNC:CAPN2) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases act(p(HGNC:CAPN2)) View Subject | View Object

The active form of calpain-2 is found in 50–75% of NFTs in tauopathies including AD, but not in protein aggregates found in other diseases (47). This is consistent with another study that found equivalent calpain levels between control and AD cases, but the activity level of the enzyme isolated from AD brain tissue was increased (48). PubMed:24027553

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Tauopathies
Text Location
Review

path(MESH:"Neurofibrillary Tangles") positiveCorrelation p(HGNC:CAPN2) View Subject | View Object

The active form of calpain-2 is found in 50–75% of NFTs in tauopathies including AD, but not in protein aggregates found in other diseases (47). This is consistent with another study that found equivalent calpain levels between control and AD cases, but the activity level of the enzyme isolated from AD brain tissue was increased (48). PubMed:24027553

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Tauopathies
Text Location
Review

Out-Edges 3

p(HGNC:CAPN2) decreases bp(GO:autophagy) View Subject | View Object

Genetic knockdown of calpain 1 or calpain 2 or overexpression of their endogenous inhibitor, calpastatin, increased autophagy and cleared aggregates in SK-N-SH cells overexpressing a mutant form of Htt 103 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Huntington Disease

p(HGNC:CAPN2) decreases deg(p(HGNC:HTT, var("?"))) View Subject | View Object

Genetic knockdown of calpain 1 or calpain 2 or overexpression of their endogenous inhibitor, calpastatin, increased autophagy and cleared aggregates in SK-N-SH cells overexpressing a mutant form of Htt 103 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Huntington Disease

p(HGNC:CAPN2) positiveCorrelation path(MESH:"Neurofibrillary Tangles") View Subject | View Object

The active form of calpain-2 is found in 50–75% of NFTs in tauopathies including AD, but not in protein aggregates found in other diseases (47). This is consistent with another study that found equivalent calpain levels between control and AD cases, but the activity level of the enzyme isolated from AD brain tissue was increased (48). PubMed:24027553

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Tauopathies
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.