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p(INTERPRO:"E3 ubiquitin ligase RBR family")

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Entity

Name
E3 ubiquitin ligase RBR family
Namespace
interpro
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/interpro-names.belns

Appears in Networks 2

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Perilous journey: a tour of the ubiquitin–proteasome system v1.0.0

In-Edges 0

Out-Edges 3

p(INTERPRO:"E3 ubiquitin ligase RBR family") decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) View Subject | View Object

On the other hand, RING finger-containing E3s catalyze, most probably, direct transfer of the activated ubiquitin moiety from E2 to the E3 bound substrate PubMed:14556719

Appears in Networks:

p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA3)) View Subject | View Object

On the other hand, RING finger-containing E3s catalyze, most probably, direct transfer of the activated ubiquitin moiety from E2 to the E3 bound substrate PubMed:14556719

Appears in Networks:

p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) View Subject | View Object

Both HECT and RBR E3s are unique in comparison to the RING ligases because they catalyze an additional transthioesterification step, where ubiquitin is transferred from the E2 to the E3 before its conjugation to the protein substrate (Figure 1A) PubMed:24457024

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.