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Appears in Networks 3

In-Edges 7

complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) View Subject | View Object

The thioesterified ubiquitin passes from the E1 active site to the next member of the cascade, the E2 or ubiquitin-conjugating enzyme PubMed:24457024

complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) View Subject | View Object

E1s are multidomain enzymes that must activate ubiquitin and efficiently transfer it to the E2 active site PubMed:24457024

p(INTERPRO:"E3 ubiquitin ligase RBR family") decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) View Subject | View Object

On the other hand, RING finger-containing E3s catalyze, most probably, direct transfer of the activated ubiquitin moiety from E2 to the E3 bound substrate PubMed:14556719

p(HGNC:UBA3) regulates complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) View Subject | View Object

Some E3s can also stabilize the conformation between ubiquitin and the E2, thereby accelerating further the rate of conjugation of ubiquitin to proteins PubMed:24457024

p(INTERPRO:"U box domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) View Subject | View Object

Indeed, three recent structural studies observed the E2~ubiquitin conformation in the presence of either RING domains or the structurally related U-box domain [19–21] PubMed:24457024

path(MESH:"RING Finger Domains") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) View Subject | View Object

Indeed, three recent structural studies observed the E2~ubiquitin conformation in the presence of either RING domains or the structurally related U-box domain [19–21] PubMed:24457024

act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) View Subject | View Object

Second, there is conjugation of the ATP-activated Ub to an E2 protein (i.e., a Ub-conjugating enzyme). PubMed:22908190

Out-Edges 3

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.