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p(MGI:Fth1)

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Entity

Name
Fth1
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

a(CHEBI:heme) increases p(MGI:Fth1) View Subject | View Object

Exposure to Hb and its oxidized products increases heme overload on the AT1 cells. Heme overload induces the expression of HO-1 and iron-sequestering proteins, such as ferritin. PubMed:26974230

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Discussion

a(CHEBI:methemoglobin) increases p(MGI:Fth1) View Subject | View Object

Similarly, HbFe31 induced a significant expression H-ferritin protein (60.4062.76-fold) when compared with a 25.25 (61.91)-fold induction by HbFe21 (Figure 2D). PubMed:26974230

Appears in Networks:
Annotations
MeSH
Alveolar Epithelial Cells
Text Location
Results

p(MGI:Hp) decreases p(MGI:Fth1) View Subject | View Object

Hp attenuated HbFe21- and HbFe31-induced up-regulation of HO-1 and H-ferritin proteins (Figure 2B). PubMed:26974230

Appears in Networks:
Annotations
MeSH
Alveolar Epithelial Cells
Text Location
Results

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.