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a(GO:"Lewy body")

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Entity

Name
Lewy body
Namespace
go
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/a5b84013a08880975ca84f40999e4404b14a97e2/external/go-names.belns

Appears in Networks 3

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases v1.0.0

In-Edges 8

a(MESH:Ubiquitin) association a(GO:"Lewy body") View Subject | View Object

We soon found that DF2 strongly stained cortical and brain stem Lewy bodies in brain sections from “diffuse Lewy body disease” (Kuzuhara et al. 1988), as originally described by Kenji Kosaka (1978), who proposed that some elderly subjects dying with dementia had many cortical Lewy bodies PubMed:22908190

Appears in Networks:
Annotations
MeSH
Brain Stem
MeSH
Cerebral Cortex
MeSH
Lewy Body Disease

a(MESH:Ubiquitin) association a(GO:"Lewy body") View Subject | View Object

The DF2 immunoreactivity of Lewy bodies led us to search for similar DF2-positive inclusions, and we found that Lewy-like bodies in motor neurons in amyotrophic lateral sclerosis (ALS; Murayama et al. 1990a) and Pick bodies in Pick’s disease (Murayama et al. 1990b) were strongly reactive; the latter stained also for tau, whereas the former stained neither for tau nor a-synuclein. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Motor Neurons
MeSH
Amyotrophic Lateral Sclerosis

complex(a(GO:"Lewy body"), p(HGNC:SNCA)) hasComponent a(GO:"Lewy body") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT) association a(GO:"Lewy body") View Subject | View Object

The DF2 immunoreactivity of Lewy bodies led us to search for similar DF2-positive inclusions, and we found that Lewy-like bodies in motor neurons in amyotrophic lateral sclerosis (ALS; Murayama et al. 1990a) and Pick bodies in Pick’s disease (Murayama et al. 1990b) were strongly reactive; the latter stained also for tau, whereas the former stained neither for tau nor a-synuclein. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Motor Neurons
MeSH
Amyotrophic Lateral Sclerosis

path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") View Subject | View Object

We soon found that DF2 strongly stained cortical and brain stem Lewy bodies in brain sections from “diffuse Lewy body disease” (Kuzuhara et al. 1988), as originally described by Kenji Kosaka (1978), who proposed that some elderly subjects dying with dementia had many cortical Lewy bodies PubMed:22908190

Appears in Networks:
Annotations
MeSH
Brain Stem
MeSH
Cerebral Cortex
MeSH
Lewy Body Disease

path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") View Subject | View Object

In this dementia, Lewy bodies are abundant in cortical neurons, especially in the cingulate gyrus, in addition to their presence in the substantia nigra and locus ceruleus, their prototypical loci in Parkinson’s disease. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Gyrus Cinguli
MeSH
Locus Coeruleus
MeSH
Neurons
MeSH
Substantia Nigra
MeSH
Parkinson Disease

p(HGNC:SQSTM1) association a(GO:"Lewy body") View Subject | View Object

p62 localizes to a variety of ubiquitin-positive neuropathological inclusions including Lewy bodies in Parkinson’s disease, neurofibrillary tangles in tauopathies, polyglutamine-expanded huntingtin aggregates in Huntington’s disease, and aggregates of mutant SOD1 in familial amyotrophic lateral sclerosis [85–87]. PubMed:18930136

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:SNCA) positiveCorrelation a(GO:"Lewy body", loc(MESH:"Dopaminergic Neurons")) View Subject | View Object

The accumulation of α‐synuclein gives rise to the formation of a nucleus for the accumulation of other proteins, which ultimately leads to the formation of Lewy bodies (within the dopamine secreting cells). PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

Out-Edges 7

a(GO:"Lewy body") association a(MESH:Ubiquitin) View Subject | View Object

We soon found that DF2 strongly stained cortical and brain stem Lewy bodies in brain sections from “diffuse Lewy body disease” (Kuzuhara et al. 1988), as originally described by Kenji Kosaka (1978), who proposed that some elderly subjects dying with dementia had many cortical Lewy bodies PubMed:22908190

Appears in Networks:
Annotations
MeSH
Brain Stem
MeSH
Cerebral Cortex
MeSH
Lewy Body Disease

a(GO:"Lewy body") association a(MESH:Ubiquitin) View Subject | View Object

The DF2 immunoreactivity of Lewy bodies led us to search for similar DF2-positive inclusions, and we found that Lewy-like bodies in motor neurons in amyotrophic lateral sclerosis (ALS; Murayama et al. 1990a) and Pick bodies in Pick’s disease (Murayama et al. 1990b) were strongly reactive; the latter stained also for tau, whereas the former stained neither for tau nor a-synuclein. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Motor Neurons
MeSH
Amyotrophic Lateral Sclerosis

a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) View Subject | View Object

We soon found that DF2 strongly stained cortical and brain stem Lewy bodies in brain sections from “diffuse Lewy body disease” (Kuzuhara et al. 1988), as originally described by Kenji Kosaka (1978), who proposed that some elderly subjects dying with dementia had many cortical Lewy bodies PubMed:22908190

Appears in Networks:
Annotations
MeSH
Brain Stem
MeSH
Cerebral Cortex
MeSH
Lewy Body Disease

a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) View Subject | View Object

In this dementia, Lewy bodies are abundant in cortical neurons, especially in the cingulate gyrus, in addition to their presence in the substantia nigra and locus ceruleus, their prototypical loci in Parkinson’s disease. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Gyrus Cinguli
MeSH
Locus Coeruleus
MeSH
Neurons
MeSH
Substantia Nigra
MeSH
Parkinson Disease

a(GO:"Lewy body") association p(HGNC:MAPT) View Subject | View Object

The DF2 immunoreactivity of Lewy bodies led us to search for similar DF2-positive inclusions, and we found that Lewy-like bodies in motor neurons in amyotrophic lateral sclerosis (ALS; Murayama et al. 1990a) and Pick bodies in Pick’s disease (Murayama et al. 1990b) were strongly reactive; the latter stained also for tau, whereas the former stained neither for tau nor a-synuclein. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Motor Neurons
MeSH
Amyotrophic Lateral Sclerosis

a(GO:"Lewy body") association p(HGNC:SQSTM1) View Subject | View Object

p62 localizes to a variety of ubiquitin-positive neuropathological inclusions including Lewy bodies in Parkinson’s disease, neurofibrillary tangles in tauopathies, polyglutamine-expanded huntingtin aggregates in Huntington’s disease, and aggregates of mutant SOD1 in familial amyotrophic lateral sclerosis [85–87]. PubMed:18930136

Appears in Networks:
Annotations
MeSH
Parkinson Disease

a(GO:"Lewy body", loc(MESH:"Dopaminergic Neurons")) positiveCorrelation p(HGNC:SNCA) View Subject | View Object

The accumulation of α‐synuclein gives rise to the formation of a nucleus for the accumulation of other proteins, which ultimately leads to the formation of Lewy bodies (within the dopamine secreting cells). PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.