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path(MESH:Dementia)

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Entity

Name
Dementia
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 14

Amyloid β oligomers (AβOs) in Alzheimer’s disease v1.0.0

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. v1.0.0

This file encodes the article Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia by Choi et al, 2014

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

Nuclear receptors as therapeutic targets for Alzheimer's disease. v1.0.0

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

Inflammasome Involvement in Alzheimer’s Disease v1.0.0

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Tau in physiology and pathology v1.0.0

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases v1.0.0

In-Edges 21

a(HBP:HBP00074) increases path(MESH:Dementia) View Subject | View Object

It was also shown that soluble AβOs may directly trigger dysfunction of neural signaling, which leads to early memory loss and the progression of dementia in AD. PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
High
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Dementia) View Subject | View Object

AD is the most common form of dementia in the elderly population. The histopathology of this disease is well known to have at least four components: 1) loss of cholinergic neurotransmission, 2) deposition of extracellular Abeta peptides into plaques, 3) hyperphosphorylation of the tau protein that leads to excessive formation of neurofibrillar tangles, and 4) increased local inflammation. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Alzheimer Disease") association path(MESH:Dementia) View Subject | View Object

Alzheimer’s disease (AD) is the most common form of dementia in elderly persons. It is a neurodegenerative disease marked by decline in memory and cognitive performance, including deterioration of language as well as defects in visual and motor coordination, and eventual death (for review, see Cummings, 2004). PubMed:19293145

Appears in Networks:

path(MESH:"Alzheimer Disease") association path(MESH:Dementia) View Subject | View Object

AD is the most commonly diagnosed form of dementia and currently affects approximately 35 million individuals worldwide.7 AD is a progressive neurodegenerative disease that is characterized by a host of cognitive deficits, including impairments in learning and memory. In addition to the well-documented cognitive impairments, AD patients also display behavioral disturbances, including anxiety, depression, and psychosis PubMed:24511233

Appears in Networks:

bp(GO:"synaptic transmission, cholinergic") association path(MESH:Dementia) View Subject | View Object

Because ACh has an important role in cognitive processes, the cholinergic system is pointed as an important factor in many forms of dementia, including AD PubMed:26813123

Appears in Networks:

act(p(HGNC:CHAT)) decreases path(MESH:Dementia) View Subject | View Object

Moreover, it has been demonstrated that ChAT transcription is severely diminished in the remaining cholinergic neurons, which leads to decreased ChAT activity and progression of dementia PubMed:26813123

Appears in Networks:

bp(GO:aging) association path(MESH:Dementia) View Subject | View Object

Dementia is a debilitating condition frequent in ageing populations, and Alzheimer's Disease (AD) accounts for 70% of all dementia cases. AD is characterized by neuropathological hallmarks consisting of an accumulation of Amyloid beta peptide (Ab) in extracellular plaques, intracellular deposits of tau protein, neuronal loss and, more recently, a prominent synaptic loss was identified (Braak and Braak,1991; Masliah et al., 2001; Selkoe,1991; Spires-Jones and Hyman, 2014) PubMed:25514383

Appears in Networks:

path(MESH:"Alzheimer Disease") association path(MESH:Dementia) View Subject | View Object

Dementia is a debilitating condition frequent in ageing populations, and Alzheimer's Disease (AD) accounts for 70% of all dementia cases. AD is characterized by neuropathological hallmarks consisting of an accumulation of Amyloid beta peptide (Ab) in extracellular plaques, intracellular deposits of tau protein, neuronal loss and, more recently, a prominent synaptic loss was identified (Braak and Braak,1991; Masliah et al., 2001; Selkoe,1991; Spires-Jones and Hyman, 2014) PubMed:25514383

Appears in Networks:

path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) View Subject | View Object

Alzheimer’s disease (AD) is the leading cause of dementia in the elderly. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) View Subject | View Object

In AD, the dominant symptom is dementia, initially characterized by a loss of short-term memory which gradually develops into a loss of most higher faculties PubMed:14556719

Appears in Networks:

path(MESH:"Prion Diseases") increases path(MESH:Dementia) View Subject | View Object

They have in common a progressive development of severe motor disturbance and dementia leading to death within a fewmonths to a fewyears after diagnosis,which can be years to decades after the initial infection in transmissible cases. PubMed:14556719

Appears in Networks:

path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Dementia) View Subject | View Object

WMH is driven by cerebral small vessel disease, which causes chronic ischemia and increased risk of cognitive decline and dementia (reviewed, (Prins & Scheltens, 2015)) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

sec(a(MESH:Interleukins)) association path(MESH:Dementia) View Subject | View Object

This family serves several biological functions but if inappropriately secreted can lead to manifestation of depressive behaviors typ- ically associated with dementia onset and chronic neuroinflammation. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:IL18) positiveCorrelation path(MESH:Dementia) View Subject | View Object

Increased levels of IL-1 beta and IL-18 have been detected in serum, cerebrospinal fluid, and brains of patients with AD and in other forms of dementia [42–46]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:IL1B) positiveCorrelation path(MESH:Dementia) View Subject | View Object

Increased levels of IL-1 beta and IL-18 have been detected in serum, cerebrospinal fluid, and brains of patients with AD and in other forms of dementia [42–46]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:Tauopathies) association path(MESH:Dementia) View Subject | View Object

Dysregulation of tau proteins can produce a spectrum of neurodegenerative diseases or tauopathies characterized by dementia and tau deposition, including AD, frontotemporal dementia (FTD), Niemann- Pick disease, corticobasal degeneration (CBD), tangle-only dementia (TOD) and progressive supranuclear palsy (PSP). PubMed:29758300

Appears in Networks:

a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) View Subject | View Object

We soon found that DF2 strongly stained cortical and brain stem Lewy bodies in brain sections from “diffuse Lewy body disease” (Kuzuhara et al. 1988), as originally described by Kenji Kosaka (1978), who proposed that some elderly subjects dying with dementia had many cortical Lewy bodies PubMed:22908190

Appears in Networks:
Annotations
MeSH
Brain Stem
MeSH
Cerebral Cortex
MeSH
Lewy Body Disease

a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) View Subject | View Object

In this dementia, Lewy bodies are abundant in cortical neurons, especially in the cingulate gyrus, in addition to their presence in the substantia nigra and locus ceruleus, their prototypical loci in Parkinson’s disease. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Gyrus Cinguli
MeSH
Locus Coeruleus
MeSH
Neurons
MeSH
Substantia Nigra
MeSH
Parkinson Disease

p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:Dementia) View Subject | View Object

In AD, tau is ubiquitinated, in Parkinson’s disease and dementia with Lewy bodies, it is a-synuclein, and in ALS and FTLD-U, it is TDP-43 PubMed:22908190

Appears in Networks:

p(HGNC:MAPT) negativeCorrelation path(MESH:Dementia) View Subject | View Object

The reduction of tau levels in the brain causes dementia lacking distinctive histopathology (DLDH), the most common pathological variant of sporadic FTD PubMed:26631930

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Huntington Disease") association path(MESH:Dementia) View Subject | View Object

HD is a neurodegenerative disease characterized by an insidious onset and subsequent progression of chorea and dementia, which usually presents at the ages of 30 to 50, and its symptoms increase with age. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Huntington Disease

Out-Edges 15

path(MESH:Dementia) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

AD is the most common form of dementia in the elderly population. The histopathology of this disease is well known to have at least four components: 1) loss of cholinergic neurotransmission, 2) deposition of extracellular Abeta peptides into plaques, 3) hyperphosphorylation of the tau protein that leads to excessive formation of neurofibrillar tangles, and 4) increased local inflammation. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Dementia) association path(MESH:"Alzheimer Disease") View Subject | View Object

Alzheimer’s disease (AD) is the most common form of dementia in elderly persons. It is a neurodegenerative disease marked by decline in memory and cognitive performance, including deterioration of language as well as defects in visual and motor coordination, and eventual death (for review, see Cummings, 2004). PubMed:19293145

Appears in Networks:

path(MESH:Dementia) association path(MESH:"Alzheimer Disease") View Subject | View Object

AD is the most commonly diagnosed form of dementia and currently affects approximately 35 million individuals worldwide.7 AD is a progressive neurodegenerative disease that is characterized by a host of cognitive deficits, including impairments in learning and memory. In addition to the well-documented cognitive impairments, AD patients also display behavioral disturbances, including anxiety, depression, and psychosis PubMed:24511233

Appears in Networks:

path(MESH:Dementia) association bp(GO:"synaptic transmission, cholinergic") View Subject | View Object

Because ACh has an important role in cognitive processes, the cholinergic system is pointed as an important factor in many forms of dementia, including AD PubMed:26813123

Appears in Networks:

path(MESH:Dementia) association bp(GO:aging) View Subject | View Object

Dementia is a debilitating condition frequent in ageing populations, and Alzheimer's Disease (AD) accounts for 70% of all dementia cases. AD is characterized by neuropathological hallmarks consisting of an accumulation of Amyloid beta peptide (Ab) in extracellular plaques, intracellular deposits of tau protein, neuronal loss and, more recently, a prominent synaptic loss was identified (Braak and Braak,1991; Masliah et al., 2001; Selkoe,1991; Spires-Jones and Hyman, 2014) PubMed:25514383

Appears in Networks:

path(MESH:Dementia) association path(MESH:"Alzheimer Disease") View Subject | View Object

Dementia is a debilitating condition frequent in ageing populations, and Alzheimer's Disease (AD) accounts for 70% of all dementia cases. AD is characterized by neuropathological hallmarks consisting of an accumulation of Amyloid beta peptide (Ab) in extracellular plaques, intracellular deposits of tau protein, neuronal loss and, more recently, a prominent synaptic loss was identified (Braak and Braak,1991; Masliah et al., 2001; Selkoe,1991; Spires-Jones and Hyman, 2014) PubMed:25514383

Appears in Networks:

path(MESH:Dementia) association sec(a(MESH:Interleukins)) View Subject | View Object

This family serves several biological functions but if inappropriately secreted can lead to manifestation of depressive behaviors typ- ically associated with dementia onset and chronic neuroinflammation. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:Dementia) positiveCorrelation p(HGNC:IL1B) View Subject | View Object

Increased levels of IL-1 beta and IL-18 have been detected in serum, cerebrospinal fluid, and brains of patients with AD and in other forms of dementia [42–46]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:Dementia) positiveCorrelation p(HGNC:IL18) View Subject | View Object

Increased levels of IL-1 beta and IL-18 have been detected in serum, cerebrospinal fluid, and brains of patients with AD and in other forms of dementia [42–46]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:Dementia) association path(MESH:Tauopathies) View Subject | View Object

Dysregulation of tau proteins can produce a spectrum of neurodegenerative diseases or tauopathies characterized by dementia and tau deposition, including AD, frontotemporal dementia (FTD), Niemann- Pick disease, corticobasal degeneration (CBD), tangle-only dementia (TOD) and progressive supranuclear palsy (PSP). PubMed:29758300

Appears in Networks:

path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") View Subject | View Object

We soon found that DF2 strongly stained cortical and brain stem Lewy bodies in brain sections from “diffuse Lewy body disease” (Kuzuhara et al. 1988), as originally described by Kenji Kosaka (1978), who proposed that some elderly subjects dying with dementia had many cortical Lewy bodies PubMed:22908190

Appears in Networks:
Annotations
MeSH
Brain Stem
MeSH
Cerebral Cortex
MeSH
Lewy Body Disease

path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") View Subject | View Object

In this dementia, Lewy bodies are abundant in cortical neurons, especially in the cingulate gyrus, in addition to their presence in the substantia nigra and locus ceruleus, their prototypical loci in Parkinson’s disease. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Gyrus Cinguli
MeSH
Locus Coeruleus
MeSH
Neurons
MeSH
Substantia Nigra
MeSH
Parkinson Disease

path(MESH:Dementia) positiveCorrelation p(HGNC:SNCA, pmod(Ub)) View Subject | View Object

In AD, tau is ubiquitinated, in Parkinson’s disease and dementia with Lewy bodies, it is a-synuclein, and in ALS and FTLD-U, it is TDP-43 PubMed:22908190

Appears in Networks:

path(MESH:Dementia) negativeCorrelation p(HGNC:MAPT) View Subject | View Object

The reduction of tau levels in the brain causes dementia lacking distinctive histopathology (DLDH), the most common pathological variant of sporadic FTD PubMed:26631930

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:Dementia) association path(MESH:"Huntington Disease") View Subject | View Object

HD is a neurodegenerative disease characterized by an insidious onset and subsequent progression of chorea and dementia, which usually presents at the ages of 30 to 50, and its symptoms increase with age. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Huntington Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.