path(MESH:"Prion Diseases")

Entity

Name

Prion Diseases

Namespace

MeSH

Namespace Version

20181007

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

This family of diseases is considered to be caused by a protein component of the proteinaceous infectious (prion) particles, originally proposed to be the causative agent of these diseases by Stanley Pruisner (1982). PubMed:14556719

Recent work has highlighted a novel possible role for failure of the UPS in initiating prion disease, which can explain the cause of some cases of sporadic prion disease. PubMed:14556719

The model proposed by Lindquist and collaborators is important as it identifies malfunction of UPS as a potentially important player in prion pathogenesis PubMed:14556719

They have in common a progressive development of severe motor disturbance and dementia leading to death within a fewmonths to a fewyears after diagnosis,which can be years to decades after the initial infection in transmissible cases. PubMed:14556719

They have in common a progressive development of severe motor disturbance and dementia leading to death within a fewmonths to a fewyears after diagnosis,which can be years to decades after the initial infection in transmissible cases. PubMed:14556719

They have in common a progressive development of severe motor disturbance and dementia leading to death within a fewmonths to a fewyears after diagnosis,which can be years to decades after the initial infection in transmissible cases. PubMed:14556719

Prion disease neuropathology is characterized by widespread neuronal death, accompanied by spongiform vacuolation and astrogliosis, usually combined with widespread deposits of extracellular amyloid aggregates. PubMed:14556719

Prion disease neuropathology is characterized by widespread neuronal death, accompanied by spongiform vacuolation and astrogliosis, usually combined with widespread deposits of extracellular amyloid aggregates. PubMed:14556719

Prion disease neuropathology is characterized by widespread neuronal death, accompanied by spongiform vacuolation and astrogliosis, usually combined with widespread deposits of extracellular amyloid aggregates. PubMed:14556719

Recent work has highlighted a novel possible role for failure of the UPS in initiating prion disease, which can explain the cause of some cases of sporadic prion disease. PubMed:14556719

The model proposed by Lindquist and collaborators is important as it identifies malfunction of UPS as a potentially important player in prion pathogenesis PubMed:14556719