1. Catalog
  2. Nodes
  3. path(MESH:Death)

path(MESH:Death)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Death
Namespace
mesh
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/mesh-names.belns

Appears in Networks 5

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 10

path(MESH:"Alzheimer Disease") association path(MESH:Death) View Subject | View Object

Alzheimer’s disease (AD) is the most common form of dementia in elderly persons. It is a neurodegenerative disease marked by decline in memory and cognitive performance, including deterioration of language as well as defects in visual and motor coordination, and eventual death (for review, see Cummings, 2004). PubMed:19293145

Appears in Networks:

a(CHEBI:galanthamine) decreases path(MESH:Death) View Subject | View Object

In a double-blind study designed to assess patients survival with mild to moderately severe AD, the long-term treatment (2 years) with galantamine significantly reduced mortality and cognition decline, besides improving daily live activities in mild to moderate AD patients PubMed:26813123

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(MGI:Slc5a7) decreases path(MESH:Death) View Subject | View Object

Moreover, mice that display a disruption of CHT1 gene expression exhibit symptoms related to ACh deficit and inevitable death within an hour of birth PubMed:26813123

Appears in Networks:

path(MESH:"Prion Diseases") increases path(MESH:Death) View Subject | View Object

They have in common a progressive development of severe motor disturbance and dementia leading to death within a fewmonths to a fewyears after diagnosis,which can be years to decades after the initial infection in transmissible cases. PubMed:14556719

Appears in Networks:

a(CHEBI:"(R)-nicotine") increases path(MESH:Death) View Subject | View Object

In comparison, S(-)-nicotine was shown to be 7 times more toxic than R(+)-nicotine in rats injected intravenously PubMed:28391535

Appears in Networks:

a(CHEBI:"(S)-nicotine") increases path(MESH:Death) View Subject | View Object

In comparison, S(-)-nicotine was shown to be 7 times more toxic than R(+)-nicotine in rats injected intravenously PubMed:28391535

Appears in Networks:

a(HM:"ABO-incompatible erythrocytes") positiveCorrelation path(MESH:Death) View Subject | View Object

Surprisingly, 66% (187/282) of ABO incompatible transfusions are asymptomatic; however, 67% (19/282) result in death and 27% (76/282) in major morbidities (Bolton-Maggs et al, 2014), including DIC (Goldfinger, 1977). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:"Transfusion Reaction") positiveCorrelation path(MESH:Death) View Subject | View Object

Although acute intravascular haemolysis is a rare complication of transfusion, it is among the most feared transfusion-associated complications, principally because death may rapidly ensue. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:Thromboembolism) positiveCorrelation path(MESH:Death) View Subject | View Object

Thromboembolism is the most common cause of death in PNH patients and accounts for 40–67% of deaths for which the cause is known. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Review

path(MESH:Thrombosis) positiveCorrelation path(MESH:Death) View Subject | View Object

Data from several retrospective studies in the preeculizumab era showed that the cause of death was related to thrombosis in 22.2–37.2% of PNH patients. PubMed:29929138

Appears in Networks:
Annotations
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Introduction

Out-Edges 5

path(MESH:Death) association path(MESH:"Alzheimer Disease") View Subject | View Object

Alzheimer’s disease (AD) is the most common form of dementia in elderly persons. It is a neurodegenerative disease marked by decline in memory and cognitive performance, including deterioration of language as well as defects in visual and motor coordination, and eventual death (for review, see Cummings, 2004). PubMed:19293145

Appears in Networks:

path(MESH:Death) positiveCorrelation path(MESH:Thromboembolism) View Subject | View Object

Thromboembolism is the most common cause of death in PNH patients and accounts for 40–67% of deaths for which the cause is known. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Review

path(MESH:Death) positiveCorrelation path(MESH:"Transfusion Reaction") View Subject | View Object

Although acute intravascular haemolysis is a rare complication of transfusion, it is among the most feared transfusion-associated complications, principally because death may rapidly ensue. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:Death) positiveCorrelation a(HM:"ABO-incompatible erythrocytes") View Subject | View Object

Surprisingly, 66% (187/282) of ABO incompatible transfusions are asymptomatic; however, 67% (19/282) result in death and 27% (76/282) in major morbidities (Bolton-Maggs et al, 2014), including DIC (Goldfinger, 1977). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:Death) positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

Data from several retrospective studies in the preeculizumab era showed that the cause of death was related to thrombosis in 22.2–37.2% of PNH patients. PubMed:29929138

Appears in Networks:
Annotations
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.