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p(HGNC:SNCA, pmod(Ub))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
SNCA
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

In-Edges 5

p(HGNC:SNCA) hasVariant p(HGNC:SNCA, pmod(Ub)) View Subject | View Object

Appears in Networks:

p(HGNC:UCHL1) increases p(HGNC:SNCA, pmod(Ub)) View Subject | View Object

Mono- and diubiquitinated alphaSYN were polyubiquitinated by the enzyme, suggesting that it acts as an E4 (Koegl et al., 1999) PubMed:14556719

Appears in Networks:

p(HGNC:SNCA) positiveCorrelation p(HGNC:SNCA, pmod(Ub)) View Subject | View Object

In 1997, a-synuclein was shown to be the principal component of Lewy bodies (Spillantini et al. 1997). The accumulated a-synuclein was then shown to be ubiquitinated (Hasegawa et al. 2002). PubMed:22908190

Appears in Networks:

path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:SNCA, pmod(Ub)) View Subject | View Object

In AD, tau is ubiquitinated, in Parkinson’s disease and dementia with Lewy bodies, it is a-synuclein, and in ALS and FTLD-U, it is TDP-43 PubMed:22908190

Appears in Networks:

path(MESH:Dementia) positiveCorrelation p(HGNC:SNCA, pmod(Ub)) View Subject | View Object

In AD, tau is ubiquitinated, in Parkinson’s disease and dementia with Lewy bodies, it is a-synuclein, and in ALS and FTLD-U, it is TDP-43 PubMed:22908190

Appears in Networks:

Out-Edges 3

p(HGNC:SNCA, pmod(Ub)) positiveCorrelation p(HGNC:SNCA) View Subject | View Object

In 1997, a-synuclein was shown to be the principal component of Lewy bodies (Spillantini et al. 1997). The accumulated a-synuclein was then shown to be ubiquitinated (Hasegawa et al. 2002). PubMed:22908190

Appears in Networks:

p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:"Parkinson Disease") View Subject | View Object

In AD, tau is ubiquitinated, in Parkinson’s disease and dementia with Lewy bodies, it is a-synuclein, and in ALS and FTLD-U, it is TDP-43 PubMed:22908190

Appears in Networks:

p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:Dementia) View Subject | View Object

In AD, tau is ubiquitinated, in Parkinson’s disease and dementia with Lewy bodies, it is a-synuclein, and in ALS and FTLD-U, it is TDP-43 PubMed:22908190

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.