p(HGNC:SULF1)
Overexpression of these enzymes in H4 cells, showed a dramatic decrease in tau uptake with Sulf1 reducing uptake to 17 ± 9%, and Sulf2 reducing uptake to 36 ± 15% (Fig. 4e) PubMed:29686391
Overexpression of the constructs was confirmed with immunocytochemistry and qPCR analysis (Fig. 4f and Supplementary Fig. 3d) and the ability of the enzymes to reduce 6-O sulfation on the cell surface was confirmed by HPLC (Supplementary Fig. 3e,f) PubMed:29686391
Overexpression of the constructs was confirmed with immunocytochemistry and qPCR analysis (Fig. 4f and Supplementary Fig. 3d) and the ability of the enzymes to reduce 6-O sulfation on the cell surface was confirmed by HPLC (Supplementary Fig. 3e,f) PubMed:29686391
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.