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Entity

Name
response to stress
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 2

In-Edges 1

bp(GO:"synaptic transmission, cholinergic") association bp(GO:"response to stress") View Subject | View Object

The cholinergic system is involved in critical physiological processes, such as attention, learning, memory, stress response, wakefulness and sleep, and sensory information PubMed:26813123

Out-Edges 6

bp(GO:"response to stress") association bp(GO:"synaptic transmission, cholinergic") View Subject | View Object

The cholinergic system is involved in critical physiological processes, such as attention, learning, memory, stress response, wakefulness and sleep, and sensory information PubMed:26813123

bp(GO:"response to stress") regulates tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(MESH:"Basal Forebrain")) View Subject | View Object

Stress is another factor that can regulate ACh release in the forebrain and its function on the hypothalamic-pituitaryadrenal (HPA) system can modulate biological and emotional outcomes PubMed:26813123

bp(GO:"response to stress") increases p(HGNCGENEFAMILY:"Small heat shock proteins") View Subject | View Object

sHSPs are overexpressed upon many different types of stress as they are key components of the PN and PDR. PubMed:24563850

bp(GO:"response to stress") increases p(HGNC:HSF1, pmod(Ph)) View Subject | View Object

During elevated stress the chaperones within the repressive HSF1-containing multi-chaperone complexes bind the unfolded proteins and thus the liberated monomeric HSF1s undergo phosphorylation, trimerization and nuclear localization with increased transcriptional activity [109]. PubMed:24563850

bp(GO:"response to stress") increases p(HGNC:HSF1, loc(MESH:"Cell Nucleus")) View Subject | View Object

During elevated stress the chaperones within the repressive HSF1-containing multi-chaperone complexes bind the unfolded proteins and thus the liberated monomeric HSF1s undergo phosphorylation, trimerization and nuclear localization with increased transcriptional activity [109]. PubMed:24563850

bp(GO:"response to stress") increases act(p(HGNC:HSF1), ma(tscript)) View Subject | View Object

During elevated stress the chaperones within the repressive HSF1-containing multi-chaperone complexes bind the unfolded proteins and thus the liberated monomeric HSF1s undergo phosphorylation, trimerization and nuclear localization with increased transcriptional activity [109]. PubMed:24563850

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.