p(HGNCGENEFAMILY:"Small heat shock proteins")
sHSPs are tightly regulated by EPMs (e.g. phosphorylation) that enable them to respond upon stress and to perform their chaperone activities [25,26]. PubMed:24563850
sHSPs are overexpressed upon many different types of stress as they are key components of the PN and PDR. PubMed:24563850
Specifically, they have been found overexpressed in many different diseases including various types of cancer where they contribute in reducing proteotoxic stress [7]. PubMed:24563850
These chaperones provide high-affinity binding platforms for unfolded proteins and prevent protein aggregation specifically during stress conditions. PubMed:24563850
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.