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  3. complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA))

complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA))

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Components

Appears in Networks 1

Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0

In-Edges 1

a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) View Subject | View Object

Natural toxins such as okadaic acid, calyculin ,and fostriecin (Reviewed in Swingle et al., 2007), and endogenous nuclear inhibitors called I1 PP2A and I2 PP2A/SET (Li and Damuni, 1998), can directly bind to the catalytic subunit and inhibit the phosphatase activity of the entire family of PP2A enzymes. PubMed:24653673

Appears in Networks:

Out-Edges 3

complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) hasComponent a(CHEBI:"okadaic acid") View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) hasComponent p(HGNC:PPP2CA) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

Natural toxins such as okadaic acid, calyculin ,and fostriecin (Reviewed in Swingle et al., 2007), and endogenous nuclear inhibitors called I1 PP2A and I2 PP2A/SET (Li and Damuni, 1998), can directly bind to the catalytic subunit and inhibit the phosphatase activity of the entire family of PP2A enzymes. PubMed:24653673

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.