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r(HGNC:NOTCH1)

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Entity

Name
NOTCH1
Namespace
hgnc
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/hgnc-symbols.belns

Appears in Networks 1

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

In-Edges 1

path(MESH:D000544) causesNoChange r(HGNC:NOTCH1) View Subject | View Object

Single cell gene array studies have shown that synaptic transcripts are selectively downregulated in CBF neurons in AD, with significant reductions in synaptophysin and synaptotagmin but not synaptobrevin or SNAP29 mRNA [134,135]. Intriguingly, synaptotagmin function is related to vesicle-presynaptic membrane fusion and neurotransmitter release, suggesting that perturbations in presynaptic vesicle trafficking comprise a common event in vulnerable neuronal populations in AD. In contrast to synaptic transcripts, mRNAs encoding APP and Notch were unchanged between control and AD subjects, whereas acid hydrolase cathepsin D mRNA was upregulated in AD [134–136]. PubMed:18986241

Appears in Networks:
Annotations
MeSH
Cognitive Dysfunction

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.