a(CHEBI:"L-arginine")
Release of hemoglobin (and ultimately heme), and arginase-1 into the plasma results in binding of nitric oxide and also reduction in L-arginine, respectively, causing a relative reduction in vasodilatory effect.[14,29] PubMed:26337933
Humans with severe PE have increased arginase-1 and decreased plasma L-arginine concentrations.[14] PubMed:26337933
Platelet deposition and adhesion at sites of subintimal injury are increased by free haemoglobin or inhibition of NO production; this effect can be prevented by infusions of L-arginine, the precursor of NO (Olsen et al, 1996). PubMed:25307023
Humans with severe PE have increased arginase-1 and decreased plasma L-arginine concentrations.[14] PubMed:26337933
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