bp(GO:"GO:0006915")

Entity

Name

GO:0006915

Namespace

go

Namespace Version

20180828

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/go.belns

For example, NGF signal transduction activates the MAPK pathway, which participates in a wide array of biologic functions, including cell survival, differentiation and apoptosis [82–84]. MAPK is a serine/ threonine protein kinase which becomes activated upon phosphorylation and affects a wide variety of transcription factors [85]. PubMed:18986241

By contrast, several studies indicate that increases in cortical proNGF may result in proapoptotic signaling through binding to the p75NTR receptor. In support of this, a different form of recombinant proNGF was shown to bind p75NTR with high affinity and promote neuronal apoptosis [55]. PubMed:18986241

Recent findings indicate that the putative proapoptotic effect(s) of p75NTR-mediated proNGF signaling is dependent on interactions between p75NTR and the neurotensin receptor sortilin, a Vps10p domain trafficking protein that acts as a cell surface coreceptor with p75NTR to mediate proNGF-induced cell death. This family of receptors is acquiring increasing importance owing to its potential involvement in AD [68]. A recent study provided genetic information for a role of the proneurotrophin receptor complex comprising sortilin and p75NTR, in the mediation of neuronal viability in vivo [69]. Sortilin expression is required for p75NTR-mediated apoptosis following proNGF treatment [57], suggesting that sortilin is a p75NTR binding partner associated with the initiation of cell death [51,58] PubMed:18986241

For example, NGF signal transduction activates the MAPK pathway, which participates in a wide array of biologic functions, including cell survival, differentiation and apoptosis [82–84]. MAPK is a serine/ threonine protein kinase which becomes activated upon phosphorylation and affects a wide variety of transcription factors [85]. PubMed:18986241