p(HGNC:CHRNA7, pmod(Ph))
Genistein enhances the amplitude of ACh responses when human alpha7 nAChRs are expressed in Xe- nopus laevis oocytes by inhibiting phosphorylation of the receptor in the intracellular loop (Charpantier et al., 2005; Grønlien et al., 2007) and shows similar actions on alpha7 nAChRs of rat hippocampal and supraoptic nucleus neurons as well as human SH-SY5Y cells (Charpantier et al., 2005). PubMed:19293145
Dephosphorylation of the α7 receptor by genistein causes a significant increase of ACh-evoked responses without modifying the response time course or ACh sensitivity (71, 72). PubMed:17009926
Furthermore, Src-family kinases (SFKs) directly phosphorylate the cytoplasmic loop of α7 nAChRs in the plasma membrane. PubMed:17009926
Genistein enhances the amplitude of ACh responses when human alpha7 nAChRs are expressed in Xe- nopus laevis oocytes by inhibiting phosphorylation of the receptor in the intracellular loop (Charpantier et al., 2005; Grønlien et al., 2007) and shows similar actions on alpha7 nAChRs of rat hippocampal and supraoptic nucleus neurons as well as human SH-SY5Y cells (Charpantier et al., 2005). PubMed:19293145
In nAChRs, several phosphorylation sites (104) that control desensitization in mus- cle and 7-nAChR also contribute to end plate localization by agrin-induced tyrosine phosphorylation of the cytoskeletal protein 43K-rapsyn PubMed:23038257
Dephosphorylation of the α7 receptor by genistein causes a significant increase of ACh-evoked responses without modifying the response time course or ACh sensitivity (71, 72). PubMed:17009926
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.