p(FPLX:SRC)

Entity

Name

SRC

Namespace

FPLX

Namespace Version

20180917

Namespace URL

https://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns

The neuroprotective effects of nicotine are blocked by inhibitors of either PI3K or SRC family kinases, and nicotine evokes an increase in levels of phosphorylated AKT, B-cell chronic lymphocytic leukemia/lymphoma (BCL2), and BCL-2-like protein (Shimohama and Kihara, 2001), which are further downstream in the PI3K/AKT pathway (Fig. 3). PubMed:19293145

Furthermore, Src-family kinases (SFKs) directly phosphorylate the cytoplasmic loop of α7 nAChRs in the plasma membrane. PubMed:17009926

Although the mechanisms that regulate phosphorylation of AChRs are still essen- tially unknown, protein tyrosine phosphorylation by the SFKs has been shown to affect peripheral AChRs in various ways, depending on the tis- sue, subunit type and functional role of the receptors involved. PubMed:22040696

In Torpedo electric organ, phosphorylation of AChRs by SFKs causes subtle changes in desensitization kinetics but not in I max , the maximal current flowing through the receptor channel [141–143]. PubMed:22040696