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complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))

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Components

Appears in Networks 3

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily v1.0.1

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

In-Edges 5

a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) View Subject | View Object

In the muscle, for example, despite the coexpression of as many as five distinct subunits, only receptors of well-defined stoichiometries are expressed: (alpha1)2beta1deltagamma in noninnervated muscle and (alpha1)2beta1deltaepsilon at mature neuromuscular synapses. PubMed:19126755

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complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) View Subject | View Object

Green and colleagues (191, 365, 485) report that nAChR assembly proceeds in the endoplasmic reticulum where specific subunits are added sequentially to the receptor complex according to the conformations the complex assumes. In this model, nAChR subunits are synthesized, and initial polypeptide folding favors the rapid recognition and interaction between alpha-beta-gamma subunits to produce trimers that in turn form a structure favorable to the addition of the delta subunit and finally the second alpha subunit. PubMed:19126755

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composite(complex(p(HGNC:CHRNA1), p(HGNC:CHRND)), complex(p(HGNC:CHRNA1), p(HGNC:CHRNG)), p(HGNC:CHRNB1)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) View Subject | View Object

In another model, a somewhat different route to assembly is proposed (59, 435, 493). In this scenario, dimers between alpha-gamma and alpha-delta subunits are formed before these paired subunits subsequently interact with the beta subunit to assemble the mature pentamer. PubMed:19126755

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r(HGNC:CHRNE) decreases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) View Subject | View Object

The epsilon subunit protein outcompetes the gamma subunit for assembly into the receptor. The receptors assembled with the epsilon subunit are more stable to degradation, aggregate at the neuromuscular junction to greater density and exhibit a more rapid response to agonist (96, 275, 324). PubMed:19126755

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a(CHEBI:chlorpromazine) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) View Subject | View Object

In receptor-rich mem- branes from T. marmorata, chlorpromazine labeled the four types of subunits of the nAChR (67), and precise quantitative measurements demonstrated that it bound to just one high affinity site per 2alpha􏰀1beta􏰂1gamma􏰃1delta􏰄1 oligomer (68). PubMed:23038257

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Out-Edges 8

complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNA1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNB1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRND) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNG) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(MESH:Muscles) View Subject | View Object

In the muscle, for example, despite the coexpression of as many as five distinct subunits, only receptors of well-defined stoichiometries are expressed: (alpha1)2beta1deltagamma in noninnervated muscle and (alpha1)2beta1deltaepsilon at mature neuromuscular synapses. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) View Subject | View Object

In the immature muscle alpha1, beta1, delta and gamma nAChR subunit transcripts are made and receptors from these subunits are synthesized and transported to the cell surface. PubMed:19126755

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Text Location
Review

complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(CHEBI:chlorpromazine) View Subject | View Object

In receptor-rich mem- branes from T. marmorata, chlorpromazine labeled the four types of subunits of the nAChR (67), and precise quantitative measurements demonstrated that it bound to just one high affinity site per 2alpha􏰀1beta􏰂1gamma􏰃1delta􏰄1 oligomer (68). PubMed:23038257

Appears in Networks:

complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases p(FPLX:CHRN) View Subject | View Object

Cholinergic nicotinic receptors expressed in muscle and ganglia are comprised of two α subunits plus each of the other three PubMed:26813123

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MeSH
Ganglia
MeSH
Muscles

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.