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p(HGNC:CHRNG)

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Entity

Name
CHRNG
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 4

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily v1.0.1

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

In-Edges 8

complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNG) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNG) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNG) View Subject | View Object

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complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNG) View Subject | View Object

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complex(p(HGNC:CHRNA1), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNG) View Subject | View Object

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composite(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNG) View Subject | View Object

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complex(a(MESH:Bungarotoxins), p(HGNC:CHRNG)) hasComponent p(HGNC:CHRNG) View Subject | View Object

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p(GFAM:"Cholinergic receptors nicotinic subunits") hasMember p(HGNC:CHRNG) View Subject | View Object

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Out-Edges 2

p(HGNC:CHRNG) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

Nicotinic receptors are formed by five different subunits: α, β, δ, and γ (fetal) or ε (adult) PubMed:26813123

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act(p(HGNC:CHRNG)) increases bp(GO:"long-term synaptic potentiation") View Subject | View Object

In receptors harboring the gamma subunit, agonist-induced receptor activation results in a long-lasting open channel time. The large agonist-induced current in turn leads to local intermittent depolarization and adjustments to protein-protein interactions that favor receptor clustering. As the depolarization increases, transcription of the epsilon subunit is increased dramatically (183). PubMed:19126755

Appears in Networks:
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.