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a(MESH:"Receptors, Nicotinic")

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Entity

Name
Receptors, Nicotinic
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 5

The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily v1.0.1

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0

Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons v1.0.0

In-Edges 32

p(HGNC:CHRNB1) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

Nicotinic receptors are formed by five different subunits: α, β, δ, and γ (fetal) or ε (adult) PubMed:26813123

Appears in Networks:

p(HGNC:CHRND) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

Nicotinic receptors are formed by five different subunits: α, β, δ, and γ (fetal) or ε (adult) PubMed:26813123

Appears in Networks:

p(HGNC:CHRNG) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

Nicotinic receptors are formed by five different subunits: α, β, δ, and γ (fetal) or ε (adult) PubMed:26813123

Appears in Networks:

a(CHEBI:decamethonium) decreases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

It was now possible to follow reversible binding to these purified membranes using the nicotinic agonist decamethonium as the radioactive ligand (by the method of equilibrium dialysis that Gilbert and Müller-Hill (9) used to identify the lac repressor) PubMed:23038257

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a(MESH:"Gallamine Triethiodide") decreases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

The detergent deoxycholate gently extracted the binding protein without denaturing it, and bound decamethonium was displaced by var- ious nicotinic agonists and antagonists, including curare and Flaxedil in the order of their physiological effects PubMed:23038257

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a(CHEBI:acetylcholine) increases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

Similarly, nicotine can mimic the ACh effects on the HPA axis by activating nicotinic receptors PubMed:26813123

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a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

Similarly, nicotine can mimic the ACh effects on the HPA axis by activating nicotinic receptors PubMed:26813123

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a(PUBCHEM:9867750) increases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

Moreover, the use of M2 antagonists, such as SCH-57790 and SC-72788, can lead to blockage of M2-mediated inhibition of presynaptic release of ACh, which can activate M1 and nicotinic receptors, ameliorating cognitive impairment in AD PubMed:26813123

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:CHRNA1) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

Nicotinic receptors are formed by five different subunits: α, β, δ, and γ (fetal) or ε (adult) PubMed:26813123

Appears in Networks:

p(HGNC:CHRNA10) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNA2) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNA3) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNA4) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNA5) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNA6) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNA7) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNA9) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNB2) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNB3) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNB4) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNE) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

Nicotinic receptors are formed by five different subunits: α, β, δ, and γ (fetal) or ε (adult) PubMed:26813123

Appears in Networks:

complex(a(CHEBI:nicotine), a(MESH:"Receptors, Nicotinic")) hasComponent a(MESH:"Receptors, Nicotinic") View Subject | View Object

Appears in Networks:

a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

Contrary to anatabine, (−)-nicotine and other nicotinic acetylcholine receptors agonists and antagonists do not inhibit Aβ production by 7W CHO cells (Fig. 3). PubMed:21958873

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
CHO cell

a(PUBCHEM:11957537) decreases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

Contrary to anatabine, (−)-nicotine and other nicotinic acetylcholine receptors agonists and antagonists do not inhibit Aβ production by 7W CHO cells (Fig. 3). PubMed:21958873

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
CHO cell

a(PUBCHEM:56972222) increases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

Contrary to anatabine, (−)-nicotine and other nicotinic acetylcholine receptors agonists and antagonists do not inhibit Aβ production by 7W CHO cells (Fig. 3). PubMed:21958873

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
CHO cell

a(PUBCHEM:71311633) increases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

Contrary to anatabine, (−)-nicotine and other nicotinic acetylcholine receptors agonists and antagonists do not inhibit Aβ production by 7W CHO cells (Fig. 3). PubMed:21958873

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
CHO cell

p(HBP:"alpha-Bungarotoxin") decreases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

Contrary to anatabine, (−)-nicotine and other nicotinic acetylcholine receptors agonists and antagonists do not inhibit Aβ production by 7W CHO cells (Fig. 3). PubMed:21958873

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
CHO cell

a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

Biochemical and pharmacological studies have characterized mecamylamine as a nonselective, voltage dependent and noncompetitive receptor antagonist of neuronal nAChRs and it is often referred to as a “nicotine receptor antagonist.” PubMed:28391535

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a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

For example, some biochemical studies suggest that mecamylamine is a channel blocker that inhibits most neuronal nAChRs (e.g., [131–133]). PubMed:28391535

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a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

(-)-Nicotine activates all brain nAChR subtypes, but binds preferentially and with high affinity to α4β2 nAChRs (e.g., [12]) PubMed:28391535

Appears in Networks:

a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

This conclusion is based on the fact that the stimulus effects of nicotine are convincingly blocked by (a) mecamylamine, a voltage dependent noncompetitive channel blocker at nicotinic receptors (Fig. 3; Table 4) and (b) dihydro-β-erythrodine (DHβE), a nicotinic receptor antagonist that shows high affinity for the nAChR α4β2 subunit (Fig. 3; Table 5) but not by methyllycaconitine (MLA), a α7 nicotinic receptor antagonist (Table 5). PubMed:28391535

Appears in Networks:

a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"Receptors, Nicotinic")) View Subject | View Object

DHβE (Fig. 3) is an alkaloid found in plant seeds of Erythrina and is a competitive nAChR receptor antagonist with a preference for neuronal β2 subtypes PubMed:28391535

Appears in Networks:

Out-Edges 6

a(MESH:"Receptors, Nicotinic") increases act(a(MESH:"Hypothalamo-Hypophyseal System")) View Subject | View Object

In a work that evaluated the function of the cholinergic system in mediating the response to stress it was found that treatment of rats with the antagonist of the nicotinic receptor, mecamylamine, attenuates the activation of the HPA axis in response to a stressor agent PubMed:26813123

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act(a(MESH:"Receptors, Nicotinic")) increases bp(MESH:"Synaptic Transmission") View Subject | View Object

In the peripheral nervous system, activation of nicotinic receptors leads to rapid synaptic transmission PubMed:26813123

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Annotations
MeSH
Peripheral Nervous System

a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) View Subject | View Object

In the CNS, most of the nicotinic receptors are expressed at the presynaptic neuronal membrane and their main role is to regulate the release of neurotransmitters, whereas nicotinic receptors expressed in the peripheral nervous system are mainly post-synaptic PubMed:26813123

Appears in Networks:
Annotations
MeSH
Central Nervous System
MeSH
Membranes
MeSH
Neurons

act(a(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:synapse)) View Subject | View Object

Stimulation of nicotinic receptors present at the CNS presynaptic neuronal membrane leads to an increase in presynaptic Ca2+ concentration, which may facilitate the release of a number of neurotransmitters, such as glutamate, GABA, dopamine, serotonin, norepinephrine, as well as ACh PubMed:26813123

Appears in Networks:
Annotations
MeSH
Central Nervous System
MeSH
Membranes
MeSH
Neurons

act(a(MESH:"Receptors, Nicotinic")) increases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

However, further studies have demonstrated that nicotinic receptor activation can lead to an increase in Aβ-mediated tau phosphorylation PubMed:26813123

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(MESH:"Receptors, Nicotinic") regulates sec(a(CHEBI:serotonin)) View Subject | View Object

Also, α7- and non-α7-containing nicotinic receptors directly or indirectly (through GABAergic interneurons) modulate serotonin release in spinal cord slices230. However, the identity of the receptors that are responsible for the spinal control of nociception is currently unknown. in this process, the nicotine-induced antinociception seems to be mediated primarily by activation of calcium– calmodulin-dependent protein kinase 2, but this is not the case for supraspinal nociception control229. PubMed:19721446

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Text Location
Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.