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p(HGNC:CHRNA9)

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Entity

Name
CHRNA9
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 9

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily v1.0.1

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

Chaperoning α7 neuronal nicotinic acetylcholine receptors v1.0.0

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

In-Edges 13

complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA9)) hasComponent p(HGNC:CHRNA9) View Subject | View Object

Appears in Networks:

p(FPLX:CHRN) hasMember p(HGNC:CHRNA9) View Subject | View Object

Appears in Networks:

p(GFAM:"Cholinergic receptors nicotinic subunits") hasMember p(HGNC:CHRNA9) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) hasComponent p(HGNC:CHRNA9) View Subject | View Object

Appears in Networks:

p(HGNC:RIC3) increases p(HGNC:CHRNA9) View Subject | View Object

Osman et al. [122] find that RIC-3 expression increases the total amount of α9 AChR in CL4 cells, supporting the view that RIC-3 regulates AChR trafficking by increasing the number of mature or correctly folded receptor subunits reaching the cell surface. PubMed:22040696

Appears in Networks:

a(MESH:"Ganglia, Spinal") increases p(HGNC:CHRNA9) View Subject | View Object

α9 or a9 and α10 subunits are expressed in most immune cells, dorsal root ganglion cells, human keratinocytes and colon and breast cancer cells. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(MESH:Acetylcholine) increases act(p(HGNC:CHRNA9)) View Subject | View Object

α9 and α9-α10 nAChRs have a number of interesting characteristics: they are acti- vated by ACh but not by the classical agonist nicotine. Cho- line is also a potent selective agonist of the α9 subtype PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(MESH:Choline) increases act(p(HGNC:CHRNA9)) View Subject | View Object

α9 and α9-α10 nAChRs have a number of interesting characteristics: they are acti- vated by ACh but not by the classical agonist nicotine. Cho- line is also a potent selective agonist of the α9 subtype PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(MESH:Keratinocytes) increases p(HGNC:CHRNA9) View Subject | View Object

α9 or a9 and α10 subunits are expressed in most immune cells, dorsal root ganglion cells, human keratinocytes and colon and breast cancer cells. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(MESH:Nicotine) causesNoChange act(p(HGNC:CHRNA9)) View Subject | View Object

α9 and α9-α10 nAChRs have a number of interesting characteristics: they are acti- vated by ACh but not by the classical agonist nicotine. Cho- line is also a potent selective agonist of the α9 subtype PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(MESH:Phosphorylcholine) causesNoChange p(HGNC:CHRNA9) View Subject | View Object

whereas phosphocholine (PC) does not evoke ion current responses in Xenopus oocytes expressing functional ho- momeric α9 or heteromeric α9-α10 nAChRs [121]. How- ever, preincubation with PC attenuates choline-induced ion current changes, thus suggesting that PC is a silent agonist of these two subtypes PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9) View Subject | View Object

Lee et al. [122] have found that α9 nAChRs are ubiquitously expressed in many epithe- lial, lung and breast cancer cell lines, most of which also express α5 and α10 nAChR subunits. α9 nAChRs are also present in primary tumour and non-malignant breast tissue obtained from patients, but their expression is higher in breast cancer cells than the surrounding normal tissue. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA9) View Subject | View Object

Lee et al. [122] have found that α9 nAChRs are ubiquitously expressed in many epithe- lial, lung and breast cancer cell lines, most of which also express α5 and α10 nAChR subunits. α9 nAChRs are also present in primary tumour and non-malignant breast tissue obtained from patients, but their expression is higher in breast cancer cells than the surrounding normal tissue. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

Out-Edges 2

p(HGNC:CHRNA9) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNA9) increases path(MESH:Neoplasms) View Subject | View Object

Si- lencing α9 nAChR expression in the tumour cells reduces their proliferation and tumorigenic potential in in vitro and in vivo assays [122]. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.