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bp(MESH:"Synaptic Transmission")

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Entity

Name
Synaptic Transmission
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns

Appears in Networks 8

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Caenorhabditis elegans models of tauopathy v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

In-Edges 12

a(CHEBI:"amyloid-beta") association bp(MESH:"Synaptic Transmission") View Subject | View Object

Although excessive Abeta causes synaptic dysfunction and synapse loss [142], low levels of Abeta increase hippocampal longterm potentiation and enhances memory, indicating a novel positive, modulatory role on neurotransmission and memory [158,159] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Neurons
MeSH
Down Syndrome

a(CHEBI:acetylcholine) regulates bp(MESH:"Synaptic Transmission") View Subject | View Object

Thus, ACh can influence the strength and fidelity of various synapses and modulate overall CNS neurotransmission PubMed:26813123

Appears in Networks:
Annotations
MeSH
Central Nervous System

act(a(MESH:"Receptors, Nicotinic")) increases bp(MESH:"Synaptic Transmission") View Subject | View Object

In the peripheral nervous system, activation of nicotinic receptors leads to rapid synaptic transmission PubMed:26813123

Appears in Networks:
Annotations
MeSH
Peripheral Nervous System

bp(GO:memory) association bp(MESH:"Synaptic Transmission") View Subject | View Object

In fact, the memory deficit and neuropathology severity observed in patients exhibiting AD highly correlate with changes in hippocampal synaptic transmission, especially with changes in synaptophysin expression, a presynaptic vesicle protein PubMed:26813123

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Alzheimer Disease

p(MGI:Lynx1) decreases bp(MESH:"Synaptic Transmission") View Subject | View Object

As a consequence of nAChR hypersensitivity, lynx1 knockout mice display increased levels of Ca2+ in neurons, enhancements in synaptic efficacy, and improved learning and memory functions (Miwa et al., 2006; Darvas et al., 2009; Tekinay et al., 2009) PubMed:21482353

Appears in Networks:

p(HGNC:PRKN) association bp(MESH:"Synaptic Transmission") View Subject | View Object

On the other hand, Parkin appears to have a role in synaptic transmission that has not been described previously and that was not possible to observe in patients. PubMed:14556719

Appears in Networks:

bp(GO:endocytosis) increases bp(MESH:"Synaptic Transmission") View Subject | View Object

Although key to the survival of all cells, endocytosis supports unique neuronal functions, including aspects of synaptic transmission and plasticity underlying memory and learning. PubMed:22908190

Appears in Networks:

complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases bp(MESH:"Synaptic Transmission") View Subject | View Object

In a recent study, tau was reported to impair neurotransmission at the presynapse by binding and inhibiting synaptic vesicle transport and release, an effect mediated by the N-terminal domain (78). PubMed:29191965

Appears in Networks:

complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") View Subject | View Object

The indispensable role of NF-κB in synaptic transmission is corroborated by the fact that the mice that are deficient in neuronal p65, exhibit severe deficits in hippocampal basal synaptic transmission and long term potentiation (LTP) PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") View Subject | View Object

Given the indispensable role of NF-κB proteins in synaptic transmission and synaptic plasticity, it is not surprising that NF-κB is plays an indispensable role in cognition and behavior as well PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:RELA) increases bp(MESH:"Synaptic Transmission") View Subject | View Object

The indispensable role of NF-κB in synaptic transmission is corroborated by the fact that the mice that are deficient in neuronal p65, exhibit severe deficits in hippocampal basal synaptic transmission and long term potentiation (LTP) PubMed:28745240

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Synaptic Transmission") View Subject | View Object

In conditional neuronal NF-κB-deficient mice, loss of NF-κB signaling impaired synaptic transmission, spatial memory formation, and plasticity PubMed:25652642

Appears in Networks:

Out-Edges 3

bp(MESH:"Synaptic Transmission") association a(CHEBI:"amyloid-beta") View Subject | View Object

Although excessive Abeta causes synaptic dysfunction and synapse loss [142], low levels of Abeta increase hippocampal longterm potentiation and enhances memory, indicating a novel positive, modulatory role on neurotransmission and memory [158,159] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Neurons
MeSH
Down Syndrome

bp(MESH:"Synaptic Transmission") association bp(GO:memory) View Subject | View Object

In fact, the memory deficit and neuropathology severity observed in patients exhibiting AD highly correlate with changes in hippocampal synaptic transmission, especially with changes in synaptophysin expression, a presynaptic vesicle protein PubMed:26813123

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Alzheimer Disease

bp(MESH:"Synaptic Transmission") association p(HGNC:PRKN) View Subject | View Object

On the other hand, Parkin appears to have a role in synaptic transmission that has not been described previously and that was not possible to observe in patients. PubMed:14556719

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.