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a(CHEBI:neurotransmitter)

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Entity

Name
neurotransmitter
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 5

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

Nicotinic Receptor Abnormalities of Alzheimer’s Disease: Therapeutic Implications v1.0.0

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

In-Edges 8

a(CHEBI:acetylcholine) isA a(CHEBI:neurotransmitter) View Subject | View Object

Appears in Networks:

a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) View Subject | View Object

In the CNS, most of the nicotinic receptors are expressed at the presynaptic neuronal membrane and their main role is to regulate the release of neurotransmitters, whereas nicotinic receptors expressed in the peripheral nervous system are mainly post-synaptic PubMed:26813123

Appears in Networks:
Annotations
MeSH
Central Nervous System
MeSH
Membranes
MeSH
Neurons

a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) View Subject | View Object

alpha7 nAChR on presynaptic terminals mediate release of others neurotransmitters (Wonnacott et al., 2006), while a postsynaptic or somatic localization elicits important changes in intracellular Ca++ concentration, that can activate second messenger pathways mediating cellular processes such as neuronal survival and gene expression (Berg and Conroy, 2002; Messi et al., 1997; Morley and Happe, 2000) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Presynaptic Terminals

p(FPLX:CHRN) increases tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) View Subject | View Object

Most brain HS nAChRs reside on presynaptic terminals, where they stimulate neurotransmitter release (Gotti et al., 2006; Albuquerque et al., 2009) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Presynaptic Terminals

bp(GO:cognition) association a(CHEBI:neurotransmitter) View Subject | View Object

Activation of the nAChR modulates the release of several neurotransmitters (Kaiser et al 2000; Wonnacott 1997) that mediate important physiologic mechanisms including cognitive functions PubMed:11230871

Appears in Networks:

act(p(FPLX:CHRN)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) View Subject | View Object

Activation of the nAChR modulates the release of several neurotransmitters (Kaiser et al 2000; Wonnacott 1997) that mediate important physiologic mechanisms including cognitive functions PubMed:11230871

Appears in Networks:

p(HGNC:SEPT5) regulates sec(a(CHEBI:neurotransmitter)) View Subject | View Object

It is possible that CDCrel-1 is involved in regulating transmitter release via its role in regulating synaptic vesicle dynamics, and its accumulation in patients with a mutation in Parkin perturbs the process. PubMed:14556719

Appears in Networks:

p(HGNC:SYT11, pmod(Ub)) association sec(a(CHEBI:neurotransmitter)) View Subject | View Object

Finally, Synaptotagmin XI has also recently been reported to be a substrate of Parkin (Huynh et al., 2003). It is possible that ubiquitination of this substrate affects synaptic vesicle transport and/or transmitter release. PubMed:14556719

Appears in Networks:

Out-Edges 2

a(CHEBI:neurotransmitter) association bp(GO:cognition) View Subject | View Object

Activation of the nAChR modulates the release of several neurotransmitters (Kaiser et al 2000; Wonnacott 1997) that mediate important physiologic mechanisms including cognitive functions PubMed:11230871

Appears in Networks:

sec(a(CHEBI:neurotransmitter)) association p(HGNC:SYT11, pmod(Ub)) View Subject | View Object

Finally, Synaptotagmin XI has also recently been reported to be a substrate of Parkin (Huynh et al., 2003). It is possible that ubiquitination of this substrate affects synaptic vesicle transport and/or transmitter release. PubMed:14556719

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.